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Open Access
Peer-reviewed
Research Article
Toxicological and pharmacological assessment of AGEN1884, a novel human IgG1 anti-CTLA-4 antibody
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Randi B. Gombos,
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing
Affiliation Immuno-modulatory Drug Discovery, Agenus Incorporated, Lexington, Massachusetts, United States of America
⨯ -
Ana Gonzalez,
Roles Data curation, Formal analysis, Writing – review & editing
Affiliation Immuno-modulatory Drug Discovery, Agenus Incorporated, Lexington, Massachusetts, United States of America
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Mariana Manrique,
Roles Data curation, Formal analysis
Affiliation Immuno-modulatory Drug Discovery, Agenus Incorporated, Lexington, Massachusetts, United States of America
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Dhan Chand,
Roles Data curation, Formal analysis, Methodology
Affiliation Immuno-modulatory Drug Discovery, Agenus Incorporated, Lexington, Massachusetts, United States of America
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David Savitsky,
Roles Data curation, Writing – review & editing
Affiliation Immuno-modulatory Drug Discovery, Agenus Incorporated, Lexington, Massachusetts, United States of America
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Benjamin Morin,
Roles Data curation, Formal analysis, Methodology, Software, Visualization, Writing – review & editing
Affiliation Research Biochemistry, Agenus Incorporated, Lexington, Massachusetts, United States of America
⨯ - Ekaterina Breous-Nystrom,
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Christopher Dupont,
Roles Data curation
Affiliation Translational Biomarkers, Agenus Incorporated, Lexington, Massachusetts, United States of America
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Rebecca A. Ward,
Roles Data curation
Affiliation Immuno-modulatory Drug Discovery, Agenus Incorporated, Lexington, Massachusetts, United States of America
⨯ - Cornelia Mundt,
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Benjamin Duckless,
Roles Data curation
Affiliation Translational Biomarkers, Agenus Incorporated, Lexington, Massachusetts, United States of America
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Hao Tang,
Roles Data curation
Affiliation Translational Biomarkers, Agenus Incorporated, Lexington, Massachusetts, United States of America
⨯ -
Mark A. Findeis,
Roles Data curation, Methodology
Affiliation Research Biochemistry, Agenus Incorporated, Lexington, Massachusetts, United States of America
⨯ - Andrea Schuster,
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Jeremy D. Waight,
Roles Data curation
Affiliation Immuno-modulatory Drug Discovery, Agenus Incorporated, Lexington, Massachusetts, United States of America
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Dennis Underwood,
Roles Investigation
Affiliation Research Biochemistry, Agenus Incorporated, Lexington, Massachusetts, United States of America
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Christopher Clarke,
Roles Data curation, Formal analysis, Validation, Writing – review & editing
Affiliation Safety, Pharmacology and Toxicology, Agenus Incorporated, Lexington, Massachusetts, United States of America
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Gerd Ritter,
Roles Conceptualization
Affiliation The Ludwig Institute for Cancer Research, New York, New York, United States of America
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Taha Merghoub,
Roles Conceptualization
Affiliation Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
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David Schaer,
Roles Conceptualization
Affiliation Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
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Jedd D. Wolchok,
Roles Conceptualization
Affiliation Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
⨯ - Marc van Dijk,
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Jennifer S. Buell,
Roles Project administration
Affiliation Research and Development Management, Agenus Incorporated, Lexington, Massachusetts, United States of America
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Jean-Marie Cuillerot,
Roles Investigation
Affiliation Research and Development Management, Agenus Incorporated, Lexington, Massachusetts, United States of America
⨯ -
Robert Stein,
Roles Conceptualization, Project administration
Affiliation Research and Development Consultant, Agenus Incorporated, Lexington, Massachusetts, United States of America
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Elise E. Drouin,
Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision, Writing – review & editing
Affiliation Translational Biomarkers, Agenus Incorporated, Lexington, Massachusetts, United States of America
⨯ - [ ... ],
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Nicholas S. Wilson
Roles Conceptualization, Investigation, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing
* E-mail: nwnicholas@gmail.com
Affiliation Immuno-modulatory Drug Discovery, Agenus Incorporated, Lexington, Massachusetts, United States of America
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Toxicological and pharmacological assessment of AGEN1884, a novel human IgG1 anti-CTLA-4 antibody
- Randi B. Gombos,
- Ana Gonzalez,
- Mariana Manrique,
- Dhan Chand,
- David Savitsky,
- Benjamin Morin,
- Ekaterina Breous-Nystrom,
- Christopher Dupont,
- Rebecca A. Ward,
- Cornelia Mundt
- Published: April 4, 2018
- https://doi.org/10.1371/journal.pone.0191926