Reduced cognitive function, increased blood-brain-barrier transport and inflammatory responses, and altered brain metabolites in LDLr -/-and C57BL/6 mice fed a western diet

• Jennifer M. Rutkowsky ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing

  * E-mail: jrutkowsky@ucdavis.edu

  Affiliation Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California, United States of America

  http://orcid.org/0000-0002-0046-7693

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• Linda L. Lee,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Division of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, California, United States of America

  ⨯
• Michelle Puchowicz,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America

  ⨯
• Mari S. Golub,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Environmental Toxicology, University of California, Davis, California, United States of America

  ⨯
• Douglas E. Befroy,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Magnetic Resonance Research Center, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut, United States of America

  ⨯
• Dennis W. Wilson,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, California, United States of America

  ⨯
• Steven Anderson,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Physiology and Membrane Biology, University of California, Davis, California, United States of America

  ⨯
• Gary Cline,

  Roles Conceptualization, Formal analysis, Funding acquisition, Writing – original draft, Writing – review & editing

  Affiliation Department of Endocrinology, Yale University, New Haven, Connecticut, United States of America

  ⨯
• Jason Bini,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Yale PET Center, Department of Diagnostic Radiology, Yale University, New Haven, Connecticut, United States of America

  ⨯
• Kamil Borkowski,

  Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation West Coast Metabolomics Center, Genome Center, University of California, Davis, California, United States of America

  ⨯
• Trina A. Knotts,

  Roles Conceptualization, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California, United States of America

  ⨯
• John C. Rutledge,

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  Affiliation Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California, United States of America

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• on behalf of the Mouse Metabolic Phenotyping Center Imaging Working Group

  ¶Membership of the Mouse Metabolic Phenotyping Center Imaging Working Group is provided in the acknowledgments.

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