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Open Access
Peer-reviewed
Research Article
The peroxisome proliferator-activated receptor agonist pioglitazone and 5-lipoxygenase inhibitor zileuton have no effect on lung inflammation in healthy volunteers by positron emission tomography in a single-blind placebo-controlled cohort study
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Delphine L. Chen ,
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
* E-mail: chend@wustl.edu
Affiliations Mallinckrodt Institute of Radiology, Division of Radiological Sciences, Washington University School of Medicine, St. Louis, MO, United States of America, Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO, United States of America
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Howard J. Huang,
Roles Investigation, Methodology, Writing – review & editing
Affiliation Annette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center at Dallas, Dallas, TX, United States of America
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Derek E. Byers,
Roles Investigation, Methodology, Writing – review & editing
Affiliation Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO, United States of America
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Adrian Shifren,
Roles Investigation, Methodology, Writing – review & editing
Affiliation Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO, United States of America
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Bryan Belikoff,
Roles Methodology, Visualization, Writing – review & editing
Affiliation Mallinckrodt Institute of Radiology, Division of Radiological Sciences, Washington University School of Medicine, St. Louis, MO, United States of America
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Jacquelyn T. Engle,
Roles Data curation, Investigation, Methodology, Writing – original draft, Writing – review & editing
Affiliation Mallinckrodt Institute of Radiology, Division of Radiological Sciences, Washington University School of Medicine, St. Louis, MO, United States of America
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Elizabeth Arentson,
Roles Data curation, Investigation, Methodology, Writing – review & editing
Affiliation Mallinckrodt Institute of Radiology, Division of Radiological Sciences, Washington University School of Medicine, St. Louis, MO, United States of America
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Debra Kemp,
Roles Data curation, Investigation, Project administration
Affiliation Center for Clinical Studies, Washington University School of Medicine, St. Louis, MO, United States of America
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Sharon Phillips,
Roles Data curation, Investigation, Project administration, Writing – review & editing
Affiliation Mallinckrodt Institute of Radiology, Division of Radiological Sciences, Washington University School of Medicine, St. Louis, MO, United States of America
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David E. Scherrer,
Roles Data curation, Investigation, Methodology, Writing – review & editing
Affiliation Department of Internal Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, MO, United States of America
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Hideji Fujiwara,
Roles Data curation, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing
Affiliation Department of Internal Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, MO, United States of America
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Katherine J. Spayd,
Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing
Affiliation Mallinckrodt Institute of Radiology, Division of Radiological Sciences, Washington University School of Medicine, St. Louis, MO, United States of America
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Frank J. Brooks,
Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing
Affiliation Mallinckrodt Institute of Radiology, Division of Radiological Sciences, Washington University School of Medicine, St. Louis, MO, United States of America
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Richard A. Pierce,
Roles Investigation, Methodology, Supervision, Writing – review & editing
Affiliation Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO, United States of America
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Mario Castro,
Roles Investigation, Methodology, Writing – review & editing
Affiliation Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO, United States of America
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Warren Isakow
Roles Investigation, Methodology, Writing – review & editing
Affiliation Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO, United States of America
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The peroxisome proliferator-activated receptor agonist pioglitazone and 5-lipoxygenase inhibitor zileuton have no effect on lung inflammation in healthy volunteers by positron emission tomography in a single-blind placebo-controlled cohort study
- Delphine L. Chen,
- Howard J. Huang,
- Derek E. Byers,
- Adrian Shifren,
- Bryan Belikoff,
- Jacquelyn T. Engle,
- Elizabeth Arentson,
- Debra Kemp,
- Sharon Phillips,
- David E. Scherrer
- Published: February 7, 2018
- https://doi.org/10.1371/journal.pone.0191783