Editing of the human TRIM5 gene to introduce mutations with the potential to inhibit HIV-1

Caroline Dufour; Alix Claudel; Nicolas Joubarne; Natacha Merindol; Tara Maisonnet; Nasser Masroori; Mélodie B. Plourde; Lionel Berthoux

doi:10.1371/journal.pone.0191709

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Open Access

Peer-reviewed

Research Article

Editing of the human TRIM5 gene to introduce mutations with the potential to inhibit HIV-1

Caroline Dufour,

Roles Investigation, Writing – original draft

Affiliation Laboratory of Antiviral Immunity, Department of Medical Biology, Université du Québec à Trois-Rivières, Trois-Rivières, Québec, Canada
⨯
Alix Claudel,

Roles Investigation

Affiliation Laboratory of Antiviral Immunity, Department of Medical Biology, Université du Québec à Trois-Rivières, Trois-Rivières, Québec, Canada
⨯
Nicolas Joubarne,

Roles Investigation

Affiliation Laboratory of Antiviral Immunity, Department of Medical Biology, Université du Québec à Trois-Rivières, Trois-Rivières, Québec, Canada
⨯
Natacha Merindol,

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation Laboratory of Antiviral Immunity, Department of Medical Biology, Université du Québec à Trois-Rivières, Trois-Rivières, Québec, Canada
⨯
Tara Maisonnet,

Roles Investigation

Affiliation Laboratory of Antiviral Immunity, Department of Medical Biology, Université du Québec à Trois-Rivières, Trois-Rivières, Québec, Canada
⨯
Nasser Masroori,

Roles Investigation

Affiliation Laboratory of Antiviral Immunity, Department of Medical Biology, Université du Québec à Trois-Rivières, Trois-Rivières, Québec, Canada
⨯
Mélodie B. Plourde,

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation Laboratory of Antiviral Immunity, Department of Medical Biology, Université du Québec à Trois-Rivières, Trois-Rivières, Québec, Canada
⨯
Lionel Berthoux

Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

* E-mail: berthoux@uqtr.ca

Affiliation Laboratory of Antiviral Immunity, Department of Medical Biology, Université du Québec à Trois-Rivières, Trois-Rivières, Québec, Canada

http://orcid.org/0000-0002-7776-5058

⨯

Editing of the human TRIM5 gene to introduce mutations with the potential to inhibit HIV-1

Caroline Dufour,
Alix Claudel,
Nicolas Joubarne,
Natacha Merindol,
Tara Maisonnet,
Nasser Masroori,
Mélodie B. Plourde,
Lionel Berthoux

Published: January 26, 2018
https://doi.org/10.1371/journal.pone.0191709

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