Detection of DNA oligonucleotides with base mutations by terahertz spectroscopy and microstructures

Mingjie Tang; Mingkun Zhang; Shihan Yan; Liangping Xia; Zhongbo Yang; Chunlei Du; Hong-Liang Cui; Dongshan Wei

doi:10.1371/journal.pone.0191515

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Open Access

Peer-reviewed

Research Article

Detection of DNA oligonucleotides with base mutations by terahertz spectroscopy and microstructures

Mingjie Tang ,

Contributed equally to this work with: Mingjie Tang, Mingkun Zhang

Roles Data curation, Investigation, Writing – original draft

Affiliation Chongqing Key laboratory of Multi-Scale manufacturing Technology, Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, China
⨯
Mingkun Zhang ,

Contributed equally to this work with: Mingjie Tang, Mingkun Zhang

Roles Data curation, Investigation, Writing – original draft

Affiliation Chongqing Key laboratory of Multi-Scale manufacturing Technology, Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, China
⨯
Shihan Yan,

Roles Conceptualization, Data curation

Affiliation Chongqing Key laboratory of Multi-Scale manufacturing Technology, Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, China
⨯
Liangping Xia,

Roles Resources

Affiliation Chongqing Key laboratory of Multi-Scale manufacturing Technology, Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, China
⨯
Zhongbo Yang,

Roles Data curation

Affiliation Chongqing Key laboratory of Multi-Scale manufacturing Technology, Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, China
⨯
Chunlei Du,

Roles Supervision

Affiliation Chongqing Key laboratory of Multi-Scale manufacturing Technology, Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, China
⨯
Hong-Liang Cui,

Roles Conceptualization

Affiliations Chongqing Key laboratory of Multi-Scale manufacturing Technology, Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, China, College of Instrumentation Science and Electrical Engineering, Jilin University, Changchun, Jilin, China
⨯
Dongshan Wei

Roles Conceptualization, Formal analysis, Project administration, Supervision, Writing – review & editing

* E-mail: dswei@cigit.ac.cn

Affiliation Chongqing Key laboratory of Multi-Scale manufacturing Technology, Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, China

http://orcid.org/0000-0003-3999-3911

⨯

Detection of DNA oligonucleotides with base mutations by terahertz spectroscopy and microstructures

Mingjie Tang,
Mingkun Zhang,
Shihan Yan,
Liangping Xia,
Zhongbo Yang,
Chunlei Du,
Hong-Liang Cui,
Dongshan Wei

Published: January 24, 2018
https://doi.org/10.1371/journal.pone.0191515

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Oligonucleotides
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Hydrogen bonding
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Biochemical simulations
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Absorption
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Resonance frequency
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Microfluidics
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Mutation detection
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Dielectrics
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