A trivalent Apx-fusion protein delivered by E. coli outer membrane vesicles induce protection against Actinobacillus pleuropneumoniae of serotype 1 and 7 challenge in a murine model

• Kui Xu ,

  Contributed equally to this work with: Kui Xu, Qin Zhao

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China

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• Qin Zhao ,

  Contributed equally to this work with: Kui Xu, Qin Zhao

  Roles Conceptualization, Formal analysis, Methodology, Project administration, Resources, Software, Validation, Writing – review & editing

  Affiliation Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China

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• Xintian Wen,

  Roles Funding acquisition, Resources, Supervision

  Affiliation Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China

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• Rui Wu,

  Roles Formal analysis, Investigation, Resources, Software

  Affiliation Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China

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• Yiping Wen,

  Roles Conceptualization, Formal analysis, Funding acquisition, Resources, Visualization

  Affiliation Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China

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• Xiaobo Huang,

  Roles Conceptualization, Formal analysis, Methodology, Supervision, Visualization

  Affiliations Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China, Sichuan Science-observation Experiment Station of Veterinary Drugs and Veterinary Diagnostic Technology, Ministry of Agriculture, Chengdu, China

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• Yong Huang,

  Roles Data curation, Investigation, Resources, Software

  Affiliation Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China

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• Qigui Yan,

  Roles Data curation, Investigation, Resources, Software

  Affiliation Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China

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• Xinfeng Han,

  Roles Conceptualization, Investigation, Resources, Visualization

  Affiliation Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China

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• Xiaoping Ma,

  Roles Methodology, Resources, Visualization

  Affiliation Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China

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• Yung-Fu Chang ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Resources, Supervision, Writing – review & editing

  * E-mail: csanjie@sicau.edu.cn (SC); yc42@cornell.edu (YFC)

  Affiliation Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, United States of America

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• Sanjie Cao

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Resources, Software, Validation, Writing – review & editing

  * E-mail: csanjie@sicau.edu.cn (SC); yc42@cornell.edu (YFC)

  Affiliations Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China, Sichuan Science-observation Experiment Station of Veterinary Drugs and Veterinary Diagnostic Technology, Ministry of Agriculture, Chengdu, China, National Teaching and Experiment Center of Animal, Sichuan Agricultural University, Chengdu, China

  http://orcid.org/0000-0002-2743-4840

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