The quaternary state of polymerized human hemoglobin regulates oxygenation of breast cancer solid tumors: A theoretical and experimental study

• Donald A. Belcher,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, United States of America

  http://orcid.org/0000-0002-7633-6219

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• Julia A. Ju,

  Roles Formal analysis, Investigation, Validation, Visualization, Writing – review & editing

  Affiliation Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD, United States of America

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• Jin Hyen Baek ,

  Roles Formal analysis, Investigation

  ¶‡ Comments/contributions are an informal communication and represent my own best judgment. These comments do not bind or obligate FDA.

  Affiliation Division of Blood Components and Devices, Laboratory of Biochemistry and Vascular Biology, FDA/CBER, Silver Spring, MD, United States of America

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• Ayla Yalamanoglu ,

  Roles Formal analysis, Investigation

  ¶‡ Comments/contributions are an informal communication and represent my own best judgment. These comments do not bind or obligate FDA.

  Affiliation Division of Blood Components and Devices, Laboratory of Biochemistry and Vascular Biology, FDA/CBER, Silver Spring, MD, United States of America

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• Paul W. Buehler ,

  Roles Formal analysis, Investigation, Project administration, Resources, Supervision, Validation, Writing – review & editing

  ¶‡ Comments/contributions are an informal communication and represent my own best judgment. These comments do not bind or obligate FDA.

  Affiliation Division of Blood Components and Devices, Laboratory of Biochemistry and Vascular Biology, FDA/CBER, Silver Spring, MD, United States of America

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• Daniele M. Gilkes,

  Roles Project administration, Resources, Supervision, Validation, Writing – review & editing

  Affiliations Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD, United States of America, Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States of America

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• Andre F. Palmer

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Validation, Writing – review & editing

  * E-mail: palmer.351@osu.edu

  Affiliation William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, United States of America

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