A non-linear pharmacokinetic-pharmacodynamic relationship of metformin in healthy volunteers: An open-label, parallel group, randomized clinical study

Hyewon Chung; Jaeseong Oh; Seo Hyun Yoon; Kyung-Sang Yu; Joo-Youn Cho; Jae-Yong Chung

doi:10.1371/journal.pone.0191258

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Peer-reviewed

Research Article

A non-linear pharmacokinetic-pharmacodynamic relationship of metformin in healthy volunteers: An open-label, parallel group, randomized clinical study

Hyewon Chung,

Roles Formal analysis, Investigation, Project administration, Writing – original draft

Affiliations Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine, Seoul, Korea, Department of Clinical Pharmacology and Toxicology, Korea University Guro Hospital, Seoul, Korea
⨯
Jaeseong Oh,

Roles Formal analysis, Project administration, Writing – review & editing

Affiliations Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine, Seoul, Korea, Department of Clinical Pharmacology and Therapeutics, Seoul National University Hospital, Seoul, Korea
⨯
Seo Hyun Yoon,

Roles Formal analysis, Methodology, Writing – review & editing

Affiliations Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine, Seoul, Korea, Department of Clinical Pharmacology and Therapeutics, Seoul National University Hospital, Seoul, Korea
⨯
Kyung-Sang Yu,

Roles Conceptualization, Supervision, Writing – review & editing

Affiliations Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine, Seoul, Korea, Department of Clinical Pharmacology and Therapeutics, Seoul National University Hospital, Seoul, Korea
⨯
Joo-Youn Cho,

Roles Formal analysis, Methodology, Writing – review & editing

Affiliations Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine, Seoul, Korea, Department of Clinical Pharmacology and Therapeutics, Seoul National University Hospital, Seoul, Korea
⨯
Jae-Yong Chung

Roles Conceptualization, Data curation, Investigation, Resources, Supervision, Writing – review & editing

* E-mail: jychung@snubh.org

Affiliations Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine, Seoul, Korea, Clinical Trials Center, Seoul National University Bundang Hospital, Seongnam, Korea

http://orcid.org/0000-0003-4188-2786

⨯

A non-linear pharmacokinetic-pharmacodynamic relationship of metformin in healthy volunteers: An open-label, parallel group, randomized clinical study

Hyewon Chung,
Jaeseong Oh,
Seo Hyun Yoon,
Kyung-Sang Yu,
Joo-Youn Cho,
Jae-Yong Chung

Published: January 17, 2018
https://doi.org/10.1371/journal.pone.0191258

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