The nonlinear relationship between cerebrospinal fluid Aβ₄₂ and tau in preclinical Alzheimer’s disease

• Mony J. de Leon ,

  Contributed equally to this work with: Mony J. de Leon, Elizabeth Pirraglia

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: Mony.deLeon@nyumc.org

  Affiliation Department of Psychiatry, Center for Brain Health, NYU Medical Center, New York, New York, United States of America

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• Elizabeth Pirraglia ,

  Contributed equally to this work with: Mony J. de Leon, Elizabeth Pirraglia

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Psychiatry, Center for Brain Health, NYU Medical Center, New York, New York, United States of America, Department of Population Health, Division of Biostatistics, NYU Medical Center, New York, New York, United States of America

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• Ricardo S. Osorio,

  Roles Conceptualization, Funding acquisition, Project administration, Writing – review & editing

  Affiliations Department of Psychiatry, Center for Brain Health, NYU Medical Center, New York, New York, United States of America, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York, United States of America

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• Lidia Glodzik,

  Roles Conceptualization, Project administration, Writing – review & editing

  Affiliations Department of Psychiatry, Center for Brain Health, NYU Medical Center, New York, New York, United States of America, Department of Radiology, NYU Medical Center, New York, New York, United States of America

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• Les Saint-Louis,

  Roles Conceptualization, Data curation, Resources

  Affiliation Lennox Hill Radiology, New York, New York, United States of America

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• Hee-Jin Kim,

  Roles Conceptualization, Writing – original draft

  Affiliation Department of Neurology, Memory Unit, Hanyang University, Seoul, Korea

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• Juan Fortea,

  Roles Conceptualization, Writing – review & editing

  Affiliation Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain

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• Silvia Fossati,

  Roles Conceptualization, Writing – review & editing

  Affiliation Department of Psychiatry, Center for Brain Health, NYU Medical Center, New York, New York, United States of America

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• Eugene Laska,

  Roles Methodology, Supervision

  Affiliation Department of Psychiatry, Center for Brain Health, NYU Medical Center, New York, New York, United States of America

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• Carole Siegel,

  Roles Methodology, Supervision

  Affiliation Department of Psychiatry, Center for Brain Health, NYU Medical Center, New York, New York, United States of America

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• Tracy Butler,

  Roles Investigation, Supervision

  Affiliation Department of Psychiatry, Center for Brain Health, NYU Medical Center, New York, New York, United States of America

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• Yi Li,

  Roles Conceptualization

  Affiliation Department of Psychiatry, Center for Brain Health, NYU Medical Center, New York, New York, United States of America

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• Henry Rusinek,

  Roles Funding acquisition, Supervision

  Affiliation Department of Radiology, NYU Medical Center, New York, New York, United States of America

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• Henrik Zetterberg,

  Roles Data curation, Resources, Supervision, Writing – review & editing

  Affiliations Sahlgrenska University Hospital, University of Gothenburg, Mölndal, Sweden, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden, Department of Molecular Neuroscience, UCL Institute of Neurology, London, United Kingdom, UK Dementia Research Institute, London, United Kingdom

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• Kaj Blennow,

  Roles Conceptualization, Resources, Supervision, Writing – review & editing

  Affiliations Sahlgrenska University Hospital, University of Gothenburg, Mölndal, Sweden, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden

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• the Alzheimer’s Disease Neuroimaging Initiative ,

  ¶A complete listing of ADNI and NACC investigators can be found in the Acknowledgments.

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•  [ ... ],
• the National Alzheimer’s Coordinating Center

  ¶A complete listing of ADNI and NACC investigators can be found in the Acknowledgments.

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