Amino acid substitutions affecting aspartic acid 605 and valine 606 decrease the interaction strength between the influenza virus RNA polymerase PB2 '627' domain and the viral nucleoprotein

• Ho-Pan Hsia ,

  Contributed equally to this work with: Ho-Pan Hsia, Yin-Hua Yang

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

  Affiliation Centre for Protein Science and Crystallography, School of Life Sciences, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China

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• Yin-Hua Yang ,

  Contributed equally to this work with: Ho-Pan Hsia, Yin-Hua Yang

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Writing – original draft

  Affiliation Centre for Protein Science and Crystallography, School of Life Sciences, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China

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• Wun-Chung Szeto,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Centre for Protein Science and Crystallography, School of Life Sciences, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China

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• Benjamin E. Nilsson,

  Roles Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom

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• Chun-Yeung Lo,

  Roles Conceptualization, Investigation

  Affiliation Centre for Protein Science and Crystallography, School of Life Sciences, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China

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• Andy Ka-Leung Ng,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Centre for Protein Science and Crystallography, School of Life Sciences, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China

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• Ervin Fodor,

  Roles Resources, Supervision, Writing – review & editing

  Affiliation Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom

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• Pang-Chui Shaw

  Roles Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: pcshaw@cuhk.edu.hk

  Affiliation Centre for Protein Science and Crystallography, School of Life Sciences, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China

  http://orcid.org/0000-0001-6848-5073

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