The polymethoxy flavonoid sudachitin suppresses inflammatory bone destruction by directly inhibiting osteoclastogenesis due to reduced ROS production and MAPK activation in osteoclast precursors

• Yoko Ohyama ,

  Contributed equally to this work with: Yoko Ohyama, Junta Ito

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – review & editing

  Affiliations Division of Oral Anatomy, Meikai University School of Dentistry, Sakado, Saitama, Japan, Division of Oral and Maxillofacial Surgery, Meikai University School of Dentistry, Sakado, Saitama, Japan

  ⨯
• Junta Ito ,

  Contributed equally to this work with: Yoko Ohyama, Junta Ito

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Writing – review & editing

  * E-mail: y-hakeda@dent.meikai.ac.jp (YH); junta@josai.ac.jp (JI)

  Current address: Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Clinical Dietetics and Human Nutrition, Sakado, Saitama, Japan

  Affiliation Division of Oral Anatomy, Meikai University School of Dentistry, Sakado, Saitama, Japan

  ⨯
• Victor J. Kitano,

  Roles Investigation, Validation, Writing – review & editing

  Affiliations Division of Oral Anatomy, Meikai University School of Dentistry, Sakado, Saitama, Japan, Division of Oral and Maxillofacial Surgery, Meikai University School of Dentistry, Sakado, Saitama, Japan

  ⨯
• Jun Shimada,

  Roles Supervision, Writing – review & editing

  Affiliation Division of Oral and Maxillofacial Surgery, Meikai University School of Dentistry, Sakado, Saitama, Japan

  ⨯
• Yoshiyuki Hakeda

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: y-hakeda@dent.meikai.ac.jp (YH); junta@josai.ac.jp (JI)

  Affiliation Division of Oral Anatomy, Meikai University School of Dentistry, Sakado, Saitama, Japan

  http://orcid.org/0000-0001-7233-2600

  ⨯