Organoids with cancer stem cell-like properties secrete exosomes and HSP90 in a 3D nanoenvironment

• Takanori Eguchi ,

  Contributed equally to this work with: Takanori Eguchi, Chiharu Sogawa

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft

  * E-mail: eguchi@okayama-u.ac.jp

  Affiliations Department of Dental Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, Japan, Advanced Research Center for Oral and Craniofacial Sciences, Okayama University Dental School, Okayama, Japan

  http://orcid.org/0000-0002-3297-6126

  ⨯
• Chiharu Sogawa ,

  Contributed equally to this work with: Takanori Eguchi, Chiharu Sogawa

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation

  Affiliation Department of Dental Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, Japan

  ⨯
• Yuka Okusha,

  Roles Data curation, Investigation, Software

  Affiliation Department of Dental Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, Japan

  ⨯
• Kenta Uchibe,

  Roles Investigation, Methodology

  Affiliation Department of Oral Morphology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, Japan

  ⨯
• Ryosuke Iinuma,

  Roles Data curation, Investigation, Resources

  Affiliation JSR Life Sciences Corporation, Tsukuba, Japan

  ⨯
• Kisho Ono,

  Roles Investigation, Validation

  Affiliation Department of Dental Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, Japan

  ⨯
• Keisuke Nakano,

  Roles Investigation, Methodology, Software

  Affiliations Advanced Research Center for Oral and Craniofacial Sciences, Okayama University Dental School, Okayama, Japan, Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, Japan

  ⨯
• Jun Murakami,

  Roles Funding acquisition, Resources

  Affiliations Advanced Research Center for Oral and Craniofacial Sciences, Okayama University Dental School, Okayama, Japan, Department of Oral Diagnosis and Dent-maxillofacial Radiology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, Japan

  ⨯
• Manabu Itoh,

  Roles Data curation, Methodology, Resources

  Affiliation JSR Life Sciences Corporation, Tsukuba, Japan

  ⨯
• Kazuya Arai,

  Roles Investigation, Methodology

  Affiliation JSR Life Sciences Corporation, Tsukuba, Japan

  ⨯
• Toshifumi Fujiwara,

  Roles Validation

  Affiliation Department of Dental Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, Japan

  ⨯
• Yuri Namba,

  Roles Validation

  Affiliation Department of Dental Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, Japan

  ⨯
• Yoshiki Murata,

  Roles Validation

  Affiliation Department of Dental Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, Japan

  ⨯
• Kazumi Ohyama,

  Roles Validation

  Affiliation Radio Isotope Research Center, Okayama University Dental School, Okayama, Japan

  ⨯
• Manami Shimomura,

  Roles Resources

  Affiliation Division of Cancer Immunotherapy, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Japan

  ⨯
• Hirohiko Okamura,

  Roles Validation

  Affiliation Department of Oral Morphology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, Japan

  ⨯
• Masaharu Takigawa,

  Roles Resources

  Affiliation Advanced Research Center for Oral and Craniofacial Sciences, Okayama University Dental School, Okayama, Japan

  ⨯
• Tetsuya Nakatsura,

  Roles Resources

  Affiliation Division of Cancer Immunotherapy, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Japan

  ⨯
• Ken-ichi Kozaki,

  Roles Resources, Supervision

  Affiliation Department of Dental Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, Japan

  ⨯
• Kuniaki Okamoto,

  Roles Resources

  Affiliation Department of Dental Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, Japan

  ⨯
•  [ ... ],
• Stuart K. Calderwood

  Roles Writing – review & editing

  Affiliation Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States of America

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