A monomethyl auristatin E-conjugated antibody to guanylyl cyclase C is cytotoxic to target-expressing cells in vitro and in vivo

• Melissa Gallery ,

  Contributed equally to this work with: Melissa Gallery, Julie Zhang

  Roles Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

  Affiliation Molecular & Cellular Oncology, Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, Cambridge, MA, United States of America

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• Julie Zhang ,

  Contributed equally to this work with: Melissa Gallery, Julie Zhang

  Roles Data curation, Formal analysis, Methodology, Validation, Visualization, Writing – original draft

  Affiliation Cancer Pharmacology, Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, Cambridge, MA, United States of America

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• Daniel P. Bradley,

  Roles Conceptualization, Formal analysis, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Biomedical Imaging, Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, Cambridge, MA, United States of America

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• Pamela Brauer,

  Roles Resources

  Affiliation Protein Sciences, Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, Cambridge, MA, United States of America

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• Donna Cvet,

  Roles Investigation

  Affiliation Biomedical Imaging, Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, Cambridge, MA, United States of America

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• Jose Estevam,

  Roles Investigation, Methodology

  Affiliation Biomarker Assay & Exploratory Biology, Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, Cambridge, MA, United States of America

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• Hadi Danaee,

  Roles Investigation, Writing – review & editing

  Affiliation Biomarker Assay & Exploratory Biology, Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, Cambridge, MA, United States of America

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• Edward Greenfield,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology

  Current address: Dana-Farber Cancer Institute, Boston, MA, United States of America

  Affiliation Protein Sciences, Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, Cambridge, MA, United States of America

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• Ping Li,

  Roles Project administration, Resources

  Affiliation Protein Sciences, Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, Cambridge, MA, United States of America

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• Mark Manfredi,

  Roles Conceptualization, Data curation

  Affiliation Cancer Pharmacology, Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, Cambridge, MA, United States of America

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• Huay-Keng Loke,

  Roles Investigation, Resources

  Affiliation Oncology Biochemistry, Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, Cambridge, MA, United States of America

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• Claudia Rabino,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Molecular & Cellular Oncology, Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, Cambridge, MA, United States of America

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• Brad Stringer,

  Roles Conceptualization, Formal analysis, Investigation, Resources, Visualization, Writing – review & editing

  Affiliation Molecular Pathology, Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, Cambridge, MA, United States of America

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• Mark Williamson,

  Roles Conceptualization, Supervision, Writing – review & editing

  Affiliation US Medical Affairs, Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, Cambridge, MA, United States of America

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• Tim Wyant,

  Roles Conceptualization, Investigation, Writing – review & editing

  Affiliation Translational Medicine, Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, Cambridge, MA, United States of America

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• Johnny Yang,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation DMPK, Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, Cambridge, MA, United States of America

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• Qing Zhu,

  Roles Investigation

  Affiliation DMPK, Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, Cambridge, MA, United States of America

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• Adnan Abu-Yousif,

  Roles Data curation, Project administration, Visualization, Writing – review & editing

  Affiliation Cancer Pharmacology, Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, Cambridge, MA, United States of America

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•  [ ... ],
• O. Petter Veiby

  Roles Conceptualization, Project administration, Supervision, Writing – review & editing

  * E-mail: Petter.Veiby@takeda.com

  Affiliation Global Biotherapeutics, Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, Cambridge, MA, United States of America

  http://orcid.org/0000-0001-6230-813X

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