Light alcohol consumption has the potential to suppress hepatocellular injury and liver fibrosis in non-alcoholic fatty liver disease

Kazutoshi Yamada; Eishiro Mizukoshi; Takuya Seike; Rika Horii; Masaaki Kitahara; Hajime Sunagozaka; Kuniaki Arai; Tatsuya Yamashita; Masao Honda; Shuichi Kaneko

doi:10.1371/journal.pone.0191026

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Open Access

Peer-reviewed

Research Article

Light alcohol consumption has the potential to suppress hepatocellular injury and liver fibrosis in non-alcoholic fatty liver disease

Kazutoshi Yamada,

Roles Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan

http://orcid.org/0000-0002-4611-448X

⨯
Eishiro Mizukoshi ,

Roles Conceptualization, Data curation, Funding acquisition, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: eishirom@m-kanazawa.jp

Affiliation Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan
⨯
Takuya Seike,

Roles Investigation

Affiliation Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan
⨯
Rika Horii,

Roles Resources

Affiliation Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan
⨯
Masaaki Kitahara,

Roles Resources

Affiliation Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan
⨯
Hajime Sunagozaka,

Roles Conceptualization, Investigation, Resources

Affiliation Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan
⨯
Kuniaki Arai,

Roles Resources

Affiliation Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan
⨯
Tatsuya Yamashita,

Roles Investigation

Affiliation Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan
⨯
Masao Honda,

Roles Formal analysis, Project administration, Software, Supervision

Affiliation Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan
⨯
Shuichi Kaneko

Roles Conceptualization, Funding acquisition, Project administration, Supervision

Affiliation Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan
⨯

Light alcohol consumption has the potential to suppress hepatocellular injury and liver fibrosis in non-alcoholic fatty liver disease

Kazutoshi Yamada,
Eishiro Mizukoshi,
Takuya Seike,
Rika Horii,
Masaaki Kitahara,
Hajime Sunagozaka,
Kuniaki Arai,
Tatsuya Yamashita,
Masao Honda,
Shuichi Kaneko

Published: January 17, 2018
https://doi.org/10.1371/journal.pone.0191026

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Alcohol consumption
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Fatty liver
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Inflammation
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Gene expression
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Fibrosis
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Liver fibrosis
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