Early arthritis induces disturbances at bone nanostructural level reflected in decreased tissue hardness in an animal model of arthritis

• Bruno Vidal ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing

  * E-mail: vidal.bmc@gmail.com

  Affiliation Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal

  http://orcid.org/0000-0003-2906-4705

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• Rita Cascão,

  Roles Conceptualization, Data curation, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliation Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal

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• Mikko A. J. Finnilä,

  Roles Conceptualization, Investigation, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliations Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland, Department of Applied Physics, University of Eastern Finland, Kuopio, Finland

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• Inês P. Lopes,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal

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• Simo Saarakkala,

  Roles Supervision, Writing – review & editing

  Affiliations Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland, Medical Research Center Oulo, Oulu University, Oulu, Finland, Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland

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• Peter Zioupos,

  Roles Methodology, Supervision, Validation, Writing – review & editing

  Affiliation Biomechanics Labs, Cranfield Forensic Institute, Cranfield University, Defence Academy of the UK, Shrivenham, United Kingdom

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• Helena Canhão,

  Roles Conceptualization, Funding acquisition, Writing – review & editing

  Affiliation EpiDoC Unit, CEDOC, NOVA Medical School, NOVA University, Lisbon, Portugal

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• João E. Fonseca

  Roles Conceptualization, Funding acquisition, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliations Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal, Rheumatology Department, Centro Hospitalar de Lisboa Norte, EPE, Hospital de Santa Maria, Lisbon Academic Medical Centre, Lisbon, Portugal

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