Emergence of resistance mutations in simian immunodeficiency virus (SIV)-infected rhesus macaques receiving non-suppressive antiretroviral therapy (ART)

Benjamin Bruno Policicchio; Paola Sette; Cuiling Xu; George Haret-Richter; Tammy Dunsmore; Ivona Pandrea; Ruy M. Ribeiro; Cristian Apetrei

doi:10.1371/journal.pone.0190908

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Open Access

Peer-reviewed

Research Article

Emergence of resistance mutations in simian immunodeficiency virus (SIV)-infected rhesus macaques receiving non-suppressive antiretroviral therapy (ART)

Benjamin Bruno Policicchio ,

Contributed equally to this work with: Benjamin Bruno Policicchio, Paola Sette

Roles Conceptualization, Investigation, Validation, Writing – original draft

Affiliations Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania, United States of America
⨯
Paola Sette ,

Contributed equally to this work with: Benjamin Bruno Policicchio, Paola Sette

Roles Formal analysis, Investigation, Methodology, Validation, Writing – original draft

Affiliations Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Cuiling Xu,

Roles Formal analysis, Methodology

Affiliations Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
George Haret-Richter,

Roles Formal analysis, Investigation

Affiliations Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Tammy Dunsmore,

Roles Investigation, Methodology

Affiliations Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Ivona Pandrea,

Roles Conceptualization, Data curation, Formal analysis, Project administration, Writing – review & editing

Affiliations Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania, United States of America, Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Ruy M. Ribeiro,

Roles Conceptualization, Data curation, Formal analysis, Writing – review & editing

Affiliations Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America, Laboratorio de Biomatemática, Faculdade de Medicina, Universidade de Lisbo, Lisboa, Portugal
⨯
Cristian Apetrei

Roles Conceptualization, Data curation, Formal analysis, Methodology, Supervision, Validation, Visualization, Writing – review & editing

* E-mail: apetreic@pitt.edu

Affiliations Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania, United States of America, Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

http://orcid.org/0000-0002-0322-7185

⨯

Emergence of resistance mutations in simian immunodeficiency virus (SIV)-infected rhesus macaques receiving non-suppressive antiretroviral therapy (ART)

Benjamin Bruno Policicchio,
Paola Sette,
Cuiling Xu,
George Haret-Richter,
Tammy Dunsmore,
Ivona Pandrea,
Ruy M. Ribeiro,
Cristian Apetrei

Published: February 21, 2018
https://doi.org/10.1371/journal.pone.0190908

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SIV
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