Parallel PI3K, AKT and mTOR inhibition is required to control feedback loops that limit tumor therapy

• Anuja Sathe,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Urology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany

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• Géraldine Chalaud,

  Roles Investigation

  Affiliation Department of Urology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany

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• Immanuel Oppolzer,

  Roles Investigation

  Affiliation Department of Urology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany

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• Kit Yeng Wong,

  Roles Investigation

  Affiliation Department of Urology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany

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• Margarita von Busch,

  Roles Investigation

  Affiliation Department of Urology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany

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• Sebastian C. Schmid,

  Roles Investigation

  Affiliation Department of Urology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany

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• Zhichao Tong,

  Roles Investigation

  Affiliation Department of Urology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany

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• Margitta Retz,

  Roles Data curation, Resources, Validation, Writing – review & editing

  Affiliation Department of Urology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany

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• Juergen E. Gschwend,

  Roles Resources, Writing – review & editing

  Affiliation Department of Urology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany

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• Wolfgang A. Schulz,

  Roles Validation, Visualization, Writing – review & editing

  Affiliation Department of Urology, Medical Faculty, Heinrich Heine University Duesseldorf, Düsseldorf, Germany

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• Roman Nawroth

  Roles Conceptualization, Data curation, Funding acquisition, Project administration, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: roman.nawroth@tum.de

  Affiliation Department of Urology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany

  http://orcid.org/0000-0001-9361-7947

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