Utilization of peptide phage display to investigate hotspots on IL-17A and what it means for drug discovery

Joey P. Ting; Frances Tung; Stephen Antonysamy; Stephen Wasserman; Spencer B. Jones; Feiyu F. Zhang; Alfonso Espada; Howard Broughton; Michael J. Chalmers; Michael E. Woodman; Holly A. Bina; Jeffrey A. Dodge; Jordi Benach; Aiping Zhang; Christopher Groshong; Danalyn Manglicmot; Marijane Russell; Sepideh Afshar

doi:10.1371/journal.pone.0190850

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Peer-reviewed

Research Article

Utilization of peptide phage display to investigate hotspots on IL-17A and what it means for drug discovery

Joey P. Ting ,

Contributed equally to this work with: Joey P. Ting, Frances Tung

Roles Investigation

Affiliation Department of protein Engineering, Eli Lilly Biotechnology Center, San Diego, California, United States of America
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Frances Tung ,

Contributed equally to this work with: Joey P. Ting, Frances Tung

Roles Investigation

Affiliation Department of structural Biology, Discovery Chemistry Research and Technologies, Lilly Biotechnology Center, Eli Lilly and Company, San Diego, California, United States of America
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Stephen Antonysamy,

Roles Investigation

Affiliation Department of structural Biology, Discovery Chemistry Research and Technologies, Lilly Biotechnology Center, Eli Lilly and Company, San Diego, California, United States of America
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Stephen Wasserman,

Roles Investigation

Affiliation Department of structural Biology, Discovery Chemistry Research and Technologies, Eli Lilly and Company, Advanced Photon Source, Argonne, Illinois, United States of America
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Spencer B. Jones,

Roles Investigation

Affiliation Lilly Research Laboratories, Indianapolis, Indiana, United States of America
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Feiyu F. Zhang,

Roles Investigation

Affiliation Department of structural Biology, Discovery Chemistry Research and Technologies, Lilly Biotechnology Center, Eli Lilly and Company, San Diego, California, United States of America
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Alfonso Espada,

Roles Investigation

Affiliation Centro de Investigación Lilly, Alcobendas, Spain
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Howard Broughton,

Roles Investigation

Affiliation Centro de Investigación Lilly, Alcobendas, Spain
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Michael J. Chalmers,

Roles Investigation

Affiliation Lilly Research Laboratories, Indianapolis, Indiana, United States of America
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Michael E. Woodman,

Roles Investigation

Affiliation Lilly Research Laboratories, Indianapolis, Indiana, United States of America
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Holly A. Bina,

Roles Investigation

Affiliation Lilly Research Laboratories, Indianapolis, Indiana, United States of America
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Jeffrey A. Dodge,

Roles Investigation

Affiliation Lilly Research Laboratories, Indianapolis, Indiana, United States of America
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Jordi Benach,

Roles Investigation

Affiliation Department of structural Biology, Discovery Chemistry Research and Technologies, Eli Lilly and Company, Advanced Photon Source, Argonne, Illinois, United States of America
⨯
Aiping Zhang,

Roles Investigation

Affiliation Department of structural Biology, Discovery Chemistry Research and Technologies, Lilly Biotechnology Center, Eli Lilly and Company, San Diego, California, United States of America
⨯
Christopher Groshong,

Roles Investigation

Affiliation Department of structural Biology, Discovery Chemistry Research and Technologies, Lilly Biotechnology Center, Eli Lilly and Company, San Diego, California, United States of America
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Danalyn Manglicmot,

Roles Investigation

Affiliation Department of structural Biology, Discovery Chemistry Research and Technologies, Lilly Biotechnology Center, Eli Lilly and Company, San Diego, California, United States of America
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Marijane Russell,

Roles Investigation

Affiliation Department of structural Biology, Discovery Chemistry Research and Technologies, Lilly Biotechnology Center, Eli Lilly and Company, San Diego, California, United States of America
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[ ... ],
Sepideh Afshar

Roles Investigation

* E-mail: s.afshar@lilly.com

Affiliation Department of protein Engineering, Eli Lilly Biotechnology Center, San Diego, California, United States of America

http://orcid.org/0000-0002-9105-3946

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Utilization of peptide phage display to investigate hotspots on IL-17A and what it means for drug discovery

Joey P. Ting,
Frances Tung,
Stephen Antonysamy,
Stephen Wasserman,
Spencer B. Jones,
Feiyu F. Zhang,
Alfonso Espada,
Howard Broughton,
Michael J. Chalmers,
Michael E. Woodman

Published: January 12, 2018
https://doi.org/10.1371/journal.pone.0190850

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