Predicting effective pro-apoptotic anti-leukaemic drug combinations using co-operative dynamic BH3 profiling

Martin Grundy; Claire Seedhouse; Thomas Jones; Liban Elmi; Michael Hall; Adam Graham; Nigel Russell; Monica Pallis

doi:10.1371/journal.pone.0190682

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Open Access

Peer-reviewed

Research Article

Predicting effective pro-apoptotic anti-leukaemic drug combinations using co-operative dynamic BH3 profiling

Martin Grundy ,

Roles Funding acquisition, Investigation, Supervision, Writing – review & editing

* E-mail: m.grundy@nottingham.ac.uk

Affiliation Clinical Haematology, Nottingham University Hospitals, Nottingham, United Kingdom

http://orcid.org/0000-0002-0719-2469

⨯
Claire Seedhouse,

Roles Investigation, Supervision, Writing – review & editing

Affiliation Department of Haematology, Division of Cancer and Stem Cells, University of Nottingham, Nottingham, United Kingdom
⨯
Thomas Jones,

Roles Investigation, Writing – review & editing

Current address: Academic Unit of Molecular Oncology, Department of Oncology and Metabolism, University of Sheffield, Sheffield, United Kingdom

Affiliation Department of Haematology, Division of Cancer and Stem Cells, University of Nottingham, Nottingham, United Kingdom
⨯
Liban Elmi,

Roles Investigation, Writing – review & editing

Affiliation Department of Haematology, Division of Cancer and Stem Cells, University of Nottingham, Nottingham, United Kingdom
⨯
Michael Hall,

Roles Investigation, Writing – review & editing

Affiliation Department of Haematology, Division of Cancer and Stem Cells, University of Nottingham, Nottingham, United Kingdom
⨯
Adam Graham,

Roles Investigation, Writing – review & editing

Affiliation Department of Haematology, Division of Cancer and Stem Cells, University of Nottingham, Nottingham, United Kingdom
⨯
Nigel Russell,

Roles Funding acquisition, Supervision, Writing – review & editing

Affiliations Clinical Haematology, Nottingham University Hospitals, Nottingham, United Kingdom, Department of Haematology, Division of Cancer and Stem Cells, University of Nottingham, Nottingham, United Kingdom
⨯
Monica Pallis

Roles Conceptualization, Investigation, Supervision, Writing – original draft, Writing – review & editing

Affiliation Clinical Haematology, Nottingham University Hospitals, Nottingham, United Kingdom
⨯

Predicting effective pro-apoptotic anti-leukaemic drug combinations using co-operative dynamic BH3 profiling

Martin Grundy,
Claire Seedhouse,
Thomas Jones,
Liban Elmi,
Michael Hall,
Adam Graham,
Nigel Russell,
Monica Pallis

Published: January 3, 2018
https://doi.org/10.1371/journal.pone.0190682

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Apoptosis
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Mitochondria
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Flow cytometry
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DNA damage
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Drug therapy
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Spliceosomes
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