The sorafenib anti-relapse effect after alloHSCT is associated with heightened alloreactivity and accumulation of CD8+PD-1+ (CD279+) lymphocytes in marrow

Andrzej Lange; Emilia Jaskula; Janusz Lange; Grzegorz Dworacki; Dorota Nowak; Aleksandra Simiczyjew; Monika Mordak-Domagala; Mariola Sedzimirska

doi:10.1371/journal.pone.0190525

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Open Access

Peer-reviewed

Research Article

The sorafenib anti-relapse effect after alloHSCT is associated with heightened alloreactivity and accumulation of CD8+PD-1+ (CD279+) lymphocytes in marrow

Andrzej Lange ,

Contributed equally to this work with: Andrzej Lange, Emilia Jaskula

Roles Conceptualization, Investigation, Writing – original draft

* E-mail: lange@iitd.pan.wroc.pl

Affiliations L. Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland, Lower Silesian Center for Cellular Transplantation with National Bone Marrow Donor Registry, Wroclaw, Poland

http://orcid.org/0000-0003-3544-1853

⨯
Emilia Jaskula ,

Contributed equally to this work with: Andrzej Lange, Emilia Jaskula

Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

Affiliations L. Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland, Lower Silesian Center for Cellular Transplantation with National Bone Marrow Donor Registry, Wroclaw, Poland
⨯
Janusz Lange,

Roles Investigation, Visualization

Affiliation Lower Silesian Center for Cellular Transplantation with National Bone Marrow Donor Registry, Wroclaw, Poland
⨯
Grzegorz Dworacki,

Roles Investigation

Affiliation Department of Immunology, Poznan University of Medical Sciences, Poznan, Poland
⨯
Dorota Nowak,

Roles Investigation

Affiliation Department of Cell Pathology, Faculty of Biotechnology, University of Wroclaw, Wroclaw, Poland
⨯
Aleksandra Simiczyjew,

Roles Investigation

Affiliation Department of Cell Pathology, Faculty of Biotechnology, University of Wroclaw, Wroclaw, Poland
⨯
Monika Mordak-Domagala,

Roles Investigation

Affiliation Lower Silesian Center for Cellular Transplantation with National Bone Marrow Donor Registry, Wroclaw, Poland
⨯
Mariola Sedzimirska

Roles Investigation

Affiliation Lower Silesian Center for Cellular Transplantation with National Bone Marrow Donor Registry, Wroclaw, Poland
⨯

The sorafenib anti-relapse effect after alloHSCT is associated with heightened alloreactivity and accumulation of CD8+PD-1+ (CD279+) lymphocytes in marrow

Andrzej Lange,
Emilia Jaskula,
Janusz Lange,
Grzegorz Dworacki,
Dorota Nowak,
Aleksandra Simiczyjew,
Monika Mordak-Domagala,
Mariola Sedzimirska

Published: January 5, 2018
https://doi.org/10.1371/journal.pone.0190525

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CD coreceptors
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