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Open Access

Peer-reviewed

Research Article

From in vivo to in vitro: Major metabolic alterations take place in hepatocytes during and following isolation

Shamir Cassim,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Laboratoire d’hépatologie cellulaire, Centre de recherche du Centre hospitalier de l’Université de Montréal (CRCHUM), Montréal, Québec, Canada
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Valérie-Ann Raymond,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

Affiliation Laboratoire d’hépatologie cellulaire, Centre de recherche du Centre hospitalier de l’Université de Montréal (CRCHUM), Montréal, Québec, Canada
⨯
Pascal Lapierre,

Roles Data curation, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

Affiliations Laboratoire d’hépatologie cellulaire, Centre de recherche du Centre hospitalier de l’Université de Montréal (CRCHUM), Montréal, Québec, Canada, Département de médecine, Université de Montréal, Montréal, Québec, Canada
⨯
Marc Bilodeau

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Writing – review & editing

* E-mail: marc.bilodeau@umontreal.ca

Affiliations Laboratoire d’hépatologie cellulaire, Centre de recherche du Centre hospitalier de l’Université de Montréal (CRCHUM), Montréal, Québec, Canada, Département de médecine, Université de Montréal, Montréal, Québec, Canada
⨯

From in vivo to in vitro: Major metabolic alterations take place in hepatocytes during and following isolation

Shamir Cassim,
Valérie-Ann Raymond,
Pascal Lapierre,
Marc Bilodeau

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Published: December 28, 2017
https://doi.org/10.1371/journal.pone.0190366

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Hepatocytes
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Cell cultures
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Cell metabolism
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Collagenases
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Mitochondria
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Xenobiotic metabolism
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Bioenergetics
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Citric acid cycle
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