Intravenously delivered mesenchymal stem cell-derived exosomes target M2-type macrophages in the injured spinal cord

Karen L. Lankford; Edgardo J. Arroyo; Katarzyna Nazimek; Krzysztof Bryniarski; Philip W. Askenase; Jeffery D. Kocsis

doi:10.1371/journal.pone.0190358

Loading metrics

Open Access

Peer-reviewed

Research Article

Intravenously delivered mesenchymal stem cell-derived exosomes target M2-type macrophages in the injured spinal cord

Karen L. Lankford,

Roles Conceptualization, Data curation, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliations Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, United States of America, Center for Neuroscience Regeneration Research, VA Connecticut Healthcare System, West Haven, Connecticut, United States of America
⨯
Edgardo J. Arroyo,

Roles Methodology, Writing – review & editing

Affiliations Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, United States of America, Center for Neuroscience Regeneration Research, VA Connecticut Healthcare System, West Haven, Connecticut, United States of America
⨯
Katarzyna Nazimek,

Roles Methodology

Affiliations Department of Immunology, Jagiellonian University College of Medicine, Krakow; Poland, Section of Allergy and Clinical Immunology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Krzysztof Bryniarski,

Roles Methodology, Writing – review & editing

Affiliations Department of Immunology, Jagiellonian University College of Medicine, Krakow; Poland, Section of Allergy and Clinical Immunology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Philip W. Askenase,

Roles Conceptualization, Writing – review & editing

Affiliation Section of Allergy and Clinical Immunology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Jeffery D. Kocsis

Roles Conceptualization, Funding acquisition, Investigation, Writing – review & editing

* E-mail: jeffery.kocsis@yale.edu

Affiliations Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, United States of America, Center for Neuroscience Regeneration Research, VA Connecticut Healthcare System, West Haven, Connecticut, United States of America

http://orcid.org/0000-0002-3780-7719

⨯

Intravenously delivered mesenchymal stem cell-derived exosomes target M2-type macrophages in the injured spinal cord

Karen L. Lankford,
Edgardo J. Arroyo,
Katarzyna Nazimek,
Krzysztof Bryniarski,
Philip W. Askenase,
Jeffery D. Kocsis

Published: January 2, 2018
https://doi.org/10.1371/journal.pone.0190358

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Exosomes
Is the Subject Area "Exosomes" applicable to this article?

Thanks for your feedback.
Spinal cord
Is the Subject Area "Spinal cord" applicable to this article?

Thanks for your feedback.
Spinal cord injury
Is the Subject Area "Spinal cord injury" applicable to this article?

Thanks for your feedback.
Macrophages
Is the Subject Area "Macrophages" applicable to this article?

Thanks for your feedback.
Spleen
Is the Subject Area "Spleen" applicable to this article?

Thanks for your feedback.
Mesenchymal stem cells
Is the Subject Area "Mesenchymal stem cells" applicable to this article?

Thanks for your feedback.
DAPI staining
Is the Subject Area "DAPI staining" applicable to this article?

Thanks for your feedback.
Fluorescence imaging
Is the Subject Area "Fluorescence imaging" applicable to this article?

Thanks for your feedback.