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Open Access
Peer-reviewed
Research Article
Modulation of the diet and gastrointestinal microbiota normalizes systemic inflammation and β-cell chemokine expression associated with autoimmune diabetes susceptibility
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Angela M. Henschel,
Roles Conceptualization, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing
Affiliations The Max McGee National Research Center for Juvenile Diabetes at the Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America, The Department of Pediatrics at the Medical College of Wisconsin, and The Children’s Research Institute of Children’s Hospital of Wisconsin, Milwaukee, Wisconsin, United States of America
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Susanne M. Cabrera,
Roles Investigation, Methodology, Writing – review & editing
Affiliations The Max McGee National Research Center for Juvenile Diabetes at the Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America, The Department of Pediatrics at the Medical College of Wisconsin, and The Children’s Research Institute of Children’s Hospital of Wisconsin, Milwaukee, Wisconsin, United States of America
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Mary L. Kaldunski,
Roles Data curation, Investigation, Methodology, Visualization
Affiliations The Max McGee National Research Center for Juvenile Diabetes at the Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America, The Department of Pediatrics at the Medical College of Wisconsin, and The Children’s Research Institute of Children’s Hospital of Wisconsin, Milwaukee, Wisconsin, United States of America
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Shuang Jia,
Roles Data curation, Formal analysis, Software, Visualization
Affiliations The Max McGee National Research Center for Juvenile Diabetes at the Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America, The Department of Pediatrics at the Medical College of Wisconsin, and The Children’s Research Institute of Children’s Hospital of Wisconsin, Milwaukee, Wisconsin, United States of America
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Rhonda Geoffrey,
Roles Investigation, Methodology, Visualization
Affiliations The Max McGee National Research Center for Juvenile Diabetes at the Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America, The Department of Pediatrics at the Medical College of Wisconsin, and The Children’s Research Institute of Children’s Hospital of Wisconsin, Milwaukee, Wisconsin, United States of America
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Mark F. Roethle,
Roles Investigation, Visualization
Affiliations The Max McGee National Research Center for Juvenile Diabetes at the Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America, The Department of Pediatrics at the Medical College of Wisconsin, and The Children’s Research Institute of Children’s Hospital of Wisconsin, Milwaukee, Wisconsin, United States of America
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Vy Lam,
Roles Data curation, Formal analysis, Software, Visualization
Affiliation The Department of Pediatrics at the Medical College of Wisconsin, and The Children’s Research Institute of Children’s Hospital of Wisconsin, Milwaukee, Wisconsin, United States of America
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Yi-Guang Chen,
Roles Conceptualization, Resources, Writing – review & editing
Affiliations The Max McGee National Research Center for Juvenile Diabetes at the Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America, The Department of Pediatrics at the Medical College of Wisconsin, and The Children’s Research Institute of Children’s Hospital of Wisconsin, Milwaukee, Wisconsin, United States of America
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Xujing Wang,
Roles Data curation, Formal analysis, Software, Writing – review & editing
Affiliation National Institute of Diabetes and Digestive and Kidney Diseases, the National Institutes of Health, Bethesda, Maryland, United States of America
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Nita H. Salzman,
Roles Conceptualization, Resources, Writing – review & editing
Affiliation The Department of Pediatrics at the Medical College of Wisconsin, and The Children’s Research Institute of Children’s Hospital of Wisconsin, Milwaukee, Wisconsin, United States of America
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Martin J. Hessner
Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
* E-mail: mhessner@mcw.edu
Affiliations The Max McGee National Research Center for Juvenile Diabetes at the Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America, The Department of Pediatrics at the Medical College of Wisconsin, and The Children’s Research Institute of Children’s Hospital of Wisconsin, Milwaukee, Wisconsin, United States of America
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Modulation of the diet and gastrointestinal microbiota normalizes systemic inflammation and β-cell chemokine expression associated with autoimmune diabetes susceptibility
- Angela M. Henschel,
- Susanne M. Cabrera,
- Mary L. Kaldunski,
- Shuang Jia,
- Rhonda Geoffrey,
- Mark F. Roethle,
- Vy Lam,
- Yi-Guang Chen,
- Xujing Wang,
- Nita H. Salzman
- Published: January 2, 2018
- https://doi.org/10.1371/journal.pone.0190351