Pharmacological activation of TRPV4 produces immediate cell damage and induction of apoptosis in human melanoma cells and HaCaT keratinocytes

• Aida Olivan-Viguera ,

  Contributed equally to this work with: Aida Olivan-Viguera, Angel Luis Garcia-Otin

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliations Biosignal Interpretation and Computational Simulation (BSICoS), Aragón Institute of Engineering Research (I3A), University of Zaragoza, Zaragoza, Spain, Instituto de Investigación Sanitaria (IIS) Aragón, Zaragoza, Spain

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• Angel Luis Garcia-Otin ,

  Contributed equally to this work with: Aida Olivan-Viguera, Angel Luis Garcia-Otin

  Roles Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Writing – review & editing

  Affiliations Instituto de Investigación Sanitaria (IIS) Aragón, Zaragoza, Spain, Aragón Institute of Health Sciences (IACS), Zaragoza, Spain

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• Javier Lozano-Gerona,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliations Instituto de Investigación Sanitaria (IIS) Aragón, Zaragoza, Spain, Aragón Institute of Health Sciences (IACS), Zaragoza, Spain

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• Edgar Abarca-Lachen,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation Universidad San Jorge, Faculty of Health Sciences, Villanueva de Gállego, Spain

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• Ana J. Garcia-Malinis,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Dept. of Dermatology, Hospital San Jorge, Huesca, Spain

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• Kirk L. Hamilton,

  Roles Formal analysis, Funding acquisition, Writing – review & editing

  Affiliation Dept. of Physiology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand

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• Yolanda Gilaberte,

  Roles Formal analysis, Investigation, Resources, Writing – review & editing

  Affiliations Dept. of Dermatology, Hospital San Jorge, Huesca, Spain, Dept. of Dermatology, University Hospital Miguel Servet, Zaragoza, Spain

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• Esther Pueyo,

  Roles Formal analysis, Funding acquisition, Methodology, Resources, Writing – review & editing

  Affiliations Biosignal Interpretation and Computational Simulation (BSICoS), Aragón Institute of Engineering Research (I3A), University of Zaragoza, Zaragoza, Spain, Instituto de Investigación Sanitaria (IIS) Aragón, Zaragoza, Spain, Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 50018-Zaragoza, Spain

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• Ralf Köhler

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft

  * E-mail: rkohler.iacs@aragon.es

  Affiliations Instituto de Investigación Sanitaria (IIS) Aragón, Zaragoza, Spain, Aragón Institute of Health Sciences (IACS), Zaragoza, Spain, Aragón Agency for Research and Development (ARAID), Zaragoza, Spain

  http://orcid.org/0000-0001-9563-2913

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