Atomistic simulations and network-based modeling of the Hsp90-Cdc37 chaperone binding with Cdk4 client protein: A mechanism of chaperoning kinase clients by exploiting weak spots of intrinsically dynamic kinase domains

• Josh Czemeres,

  Roles Data curation, Formal analysis, Investigation, Validation, Visualization

  Affiliation Department of Computational and Data Sciences, Schmid College of Science and Technology, Chapman University, Orange, California, United States of America

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• Kurt Buse,

  Roles Data curation, Formal analysis, Validation, Visualization

  Affiliation Department of Computational and Data Sciences, Schmid College of Science and Technology, Chapman University, Orange, California, United States of America

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• Gennady M. Verkhivker

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: verkhivk@chapman.edu

  Affiliations Department of Computational and Data Sciences, Schmid College of Science and Technology, Chapman University, Orange, California, United States of America, Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Irvine, California, United States of America

  http://orcid.org/0000-0002-4507-4471

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