MAC-sparing effect of nitrous oxide in sevoflurane anesthetized sheep and its reversal with systemic atipamezole administration

• Lauren Duffee ,

  Contributed equally to this work with: Lauren Duffee, Nicolò Columbano, Bernd Driessen

  Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  * E-mail: lduffee@upenn.edu

  Affiliation Department of Clinical Studies-New Bolton Center, University of Pennsylvania, School of Veterinary Medicine, Kennett Square, Pennsylvania, United States of America

  http://orcid.org/0000-0002-3613-3396

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• Nicolò Columbano ,

  Contributed equally to this work with: Lauren Duffee, Nicolò Columbano, Bernd Driessen

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Resources, Writing – review & editing

  Affiliations Dipartimento di Medicina Veterinaria, Università degli Studi di Sassari, Sassari, Sardegna, Italy, Centro di Ricerca di Chirurgia Comparata (CRCC), Università degli Studi di Sassari, Sassari, Sardegna, Italy

  ⨯
• Antonio Scanu ,

  Roles Investigation

  ¶‡ These authors also contributed equally to this work.

  Affiliation Dipartimento di Medicina Veterinaria, Università degli Studi di Sassari, Sassari, Sardegna, Italy

  ⨯
• Valentino Melosu,

  Roles Investigation

  Affiliation Dipartimento di Medicina Veterinaria, Università degli Studi di Sassari, Sassari, Sardegna, Italy

  ⨯
• Giovanni Mario Careddu,

  Roles Funding acquisition, Investigation, Resources

  Affiliations Dipartimento di Medicina Veterinaria, Università degli Studi di Sassari, Sassari, Sardegna, Italy, Centro di Ricerca di Chirurgia Comparata (CRCC), Università degli Studi di Sassari, Sassari, Sardegna, Italy

  ⨯
• Giovanni Sotgiu ,

  Roles Formal analysis, Writing – review & editing

  ¶‡ These authors also contributed equally to this work.

  Affiliation Dipartimento di Scienze Biomediche, Università degli Studi di Sassari, Sassari, Sardegna, Italy

  ⨯
• Bernd Driessen

  Contributed equally to this work with: Lauren Duffee, Nicolò Columbano, Bernd Driessen

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Writing – review & editing

  Affiliations Department of Clinical Studies-New Bolton Center, University of Pennsylvania, School of Veterinary Medicine, Kennett Square, Pennsylvania, United States of America, Narkovet Consulting™ LLC, Chadds Ford, PA, United States of America

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