Characterization of the acute inflammatory profile and resolution of airway inflammation after Igf1r-gene targeting in a murine model of HDM-induced asthma

Sergio Piñeiro-Hermida; Elvira Alfaro-Arnedo; Joshua A. Gregory; Raquel Torrens; Carlos Ruíz-Martínez; Mikael Adner; Icíar P. López; José G. Pichel

doi:10.1371/journal.pone.0190159

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Open Access

Peer-reviewed

Research Article

Characterization of the acute inflammatory profile and resolution of airway inflammation after Igf1r-gene targeting in a murine model of HDM-induced asthma

Sergio Piñeiro-Hermida,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Lung Cancer and Respiratory Diseases Unit, Centro de Investigación Biomédica de la Rioja (CIBIR), Fundación Rioja Salud, Logroño, Spain
⨯
Elvira Alfaro-Arnedo,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Lung Cancer and Respiratory Diseases Unit, Centro de Investigación Biomédica de la Rioja (CIBIR), Fundación Rioja Salud, Logroño, Spain
⨯
Joshua A. Gregory,

Roles Writing – review & editing

Current address: Adlego Biomedical AB, Uppsala, Sweden.

Affiliation Unit of Experimental Asthma and Allergy Research, Karolinska Institutet, Institute of Environmental Medicine (IMM), Stockholm, Sweden
⨯
Raquel Torrens,

Roles Investigation, Methodology

Affiliation Lung Cancer and Respiratory Diseases Unit, Centro de Investigación Biomédica de la Rioja (CIBIR), Fundación Rioja Salud, Logroño, Spain
⨯
Carlos Ruíz-Martínez,

Roles Writing – review & editing

Affiliation Pneumology Service, Hospital San Pedro, Logroño, Spain
⨯
Mikael Adner,

Roles Funding acquisition, Supervision, Writing – review & editing

Affiliation Unit of Experimental Asthma and Allergy Research, Karolinska Institutet, Institute of Environmental Medicine (IMM), Stockholm, Sweden
⨯
Icíar P. López,

Roles Writing – review & editing

Affiliation Lung Cancer and Respiratory Diseases Unit, Centro de Investigación Biomédica de la Rioja (CIBIR), Fundación Rioja Salud, Logroño, Spain
⨯
José G. Pichel

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: jgpichel@riojasalud.es

Affiliation Lung Cancer and Respiratory Diseases Unit, Centro de Investigación Biomédica de la Rioja (CIBIR), Fundación Rioja Salud, Logroño, Spain

http://orcid.org/0000-0001-8580-0952

⨯

Characterization of the acute inflammatory profile and resolution of airway inflammation after Igf1r-gene targeting in a murine model of HDM-induced asthma

Sergio Piñeiro-Hermida,
Elvira Alfaro-Arnedo,
Joshua A. Gregory,
Raquel Torrens,
Carlos Ruíz-Martínez,
Mikael Adner,
Icíar P. López,
José G. Pichel

Published: December 22, 2017
https://doi.org/10.1371/journal.pone.0190159

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Inflammation
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Allergies
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Asthma
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Eosinophils
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Cell enumeration techniques
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Gene expression
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