Macrophage conditioned medium promotes colorectal cancer stem cell phenotype via the hedgehog signaling pathway

Fan Fan; Rui Wang; Delphine R. Boulbes; Huiyuan Zhang; Stephanie S. Watowich; Ling Xia; Xiangcang Ye; Rajat Bhattacharya; Lee M. Ellis

doi:10.1371/journal.pone.0190070

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Open Access

Peer-reviewed

Research Article

Macrophage conditioned medium promotes colorectal cancer stem cell phenotype via the hedgehog signaling pathway

Fan Fan,

Roles Conceptualization, Formal analysis, Investigation, Writing – original draft

Affiliation Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Holcombe Boulevard, Houston, Texas, United States of America

http://orcid.org/0000-0001-6708-5430

⨯
Rui Wang,

Roles Conceptualization

Affiliation Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Holcombe Boulevard, Houston, Texas, United States of America
⨯
Delphine R. Boulbes,

Roles Conceptualization, Writing – review & editing

Affiliation Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Holcombe Boulevard, Houston, Texas, United States of America
⨯
Huiyuan Zhang,

Roles Conceptualization

Affiliation Department of Immunology, University of Texas MD Anderson Cancer Center, Holcombe Boulevard, Houston, Texas, United States of America
⨯
Stephanie S. Watowich,

Roles Conceptualization

Affiliation Department of Immunology, University of Texas MD Anderson Cancer Center, Holcombe Boulevard, Houston, Texas, United States of America
⨯
Ling Xia,

Roles Validation

Affiliation Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Holcombe Boulevard, Houston, Texas, United States of America
⨯
Xiangcang Ye,

Roles Conceptualization

Affiliation Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Holcombe Boulevard, Houston, Texas, United States of America
⨯
Rajat Bhattacharya,

Roles Conceptualization

Affiliation Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Holcombe Boulevard, Houston, Texas, United States of America
⨯
Lee M. Ellis

Roles Conceptualization, Formal analysis, Supervision, Writing – review & editing

* E-mail: lellis@mdanderson.org

Affiliation Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Holcombe Boulevard, Houston, Texas, United States of America
⨯

Macrophage conditioned medium promotes colorectal cancer stem cell phenotype via the hedgehog signaling pathway

Fan Fan,
Rui Wang,
Delphine R. Boulbes,
Huiyuan Zhang,
Stephanie S. Watowich,
Ling Xia,
Xiangcang Ye,
Rajat Bhattacharya,
Lee M. Ellis

Published: January 2, 2018
https://doi.org/10.1371/journal.pone.0190070

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Hedgehog signaling
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