Comparative analysis of the end-joining activity of several DNA ligases

Robert J. Bauer; Alexander Zhelkovsky; Katharina Bilotti; Laura E. Crowell; Thomas C. Evans Jr.; Larry A. McReynolds; Gregory J. S. Lohman

doi:10.1371/journal.pone.0190062

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Open Access

Peer-reviewed

Research Article

Comparative analysis of the end-joining activity of several DNA ligases

Robert J. Bauer ,

Contributed equally to this work with: Robert J. Bauer, Alexander Zhelkovsky

Roles Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

Current address: Biochemistry, Agios Pharmaceuticals, Cambridge, MA, United States of America

¶‡ These authors are joint first authors on this work.

Affiliation Research Division, New England Biolabs, Inc., Ipswich, MA, United States of America
⨯
Alexander Zhelkovsky ,

Contributed equally to this work with: Robert J. Bauer, Alexander Zhelkovsky

Roles Conceptualization, Investigation, Writing – original draft, Writing – review & editing

¶‡ These authors are joint first authors on this work.

Affiliation Research Division, New England Biolabs, Inc., Ipswich, MA, United States of America
⨯
Katharina Bilotti,

Roles Investigation, Writing – review & editing

Affiliation Research Division, New England Biolabs, Inc., Ipswich, MA, United States of America
⨯
Laura E. Crowell,

Roles Investigation

Current address: The David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, United States of America

Affiliation Research Division, New England Biolabs, Inc., Ipswich, MA, United States of America
⨯
Thomas C. Evans Jr.,

Roles Project administration, Supervision, Writing – review & editing

Affiliation Research Division, New England Biolabs, Inc., Ipswich, MA, United States of America
⨯
Larry A. McReynolds,

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation Research Division, New England Biolabs, Inc., Ipswich, MA, United States of America
⨯
Gregory J. S. Lohman

Roles Conceptualization, Methodology, Project administration, Supervision, Writing – review & editing

* E-mail: lohman@neb.com

Affiliation Research Division, New England Biolabs, Inc., Ipswich, MA, United States of America

http://orcid.org/0000-0002-0638-7555

⨯

Comparative analysis of the end-joining activity of several DNA ligases

Robert J. Bauer,
Alexander Zhelkovsky,
Katharina Bilotti,
Laura E. Crowell,
Thomas C. Evans Jr.,
Larry A. McReynolds,
Gregory J. S. Lohman

Published: December 28, 2017
https://doi.org/10.1371/journal.pone.0190062

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Ligases
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Ligation assay
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DNA
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DNA fragment ligation
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DNA-binding proteins
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Blunt-end ligation
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Magnesium chloride
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Anisotropy
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