Dose-Duration Reciprocity for G protein activation: Modulation of kinase to substrate ratio alters cell signaling

• Kang-Ling Liao,

  Roles Conceptualization, Formal analysis, Validation, Visualization, Writing – original draft, Writing – review & editing

  Current address: Department of Mathematics, Tamkang University, New Taipei City, Taiwan

  Affiliation Departments of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America

  ⨯
• Charles E. Melvin,

  Roles Data curation, Visualization

  Affiliation Department of Plant and Microbial Biology, North Carolina State University, Raleigh, NC, United States of America

  ⨯
• Rosangela Sozzani,

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  Affiliation Department of Plant and Microbial Biology, North Carolina State University, Raleigh, NC, United States of America

  ⨯
• Roger D. Jones,

  Roles Conceptualization, Writing – review & editing

  Affiliation Center for Complex Systems and Enterprises, Stevens Institute of Technology, Hoboken, NJ, United States of America

  ⨯
• Timothy C. Elston ,

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Writing – review & editing

  * E-mail: Alan_Jones@unc.edu (AM); timothy_elston@med.unc.edu (TC)

  Affiliation Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America

  ⨯
• Alan M. Jones

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: Alan_Jones@unc.edu (AM); timothy_elston@med.unc.edu (TC)

  Affiliations Departments of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America, Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America

  http://orcid.org/0000-0002-2365-6462

  ⨯