Consistent expression of guanylyl cyclase-C in primary and metastatic gastrointestinal cancers

Hadi Danaee; Thea Kalebic; Timothy Wyant; Matteo Fassan; Claudia Mescoli; Feng Gao; William L. Trepicchio; Massimo Rugge

doi:10.1371/journal.pone.0189953

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Open Access

Peer-reviewed

Research Article

Consistent expression of guanylyl cyclase-C in primary and metastatic gastrointestinal cancers

Hadi Danaee,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, Cambridge, Massachusetts, United States of America
⨯
Thea Kalebic ,

Roles Writing – review & editing

* E-mail: Thea.Kalebic@takeda.com

Affiliation Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, Cambridge, Massachusetts, United States of America
⨯
Timothy Wyant,

Roles Conceptualization, Formal analysis, Project administration, Resources, Supervision, Writing – review & editing

Current address: Curis, Inc., Lexington, Massachusetts, United States of America

Affiliation Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, Cambridge, Massachusetts, United States of America
⨯
Matteo Fassan,

Roles Resources, Writing – review & editing

Affiliation Department of Medicine, DIMED, Surgical Pathology and Cytopathology Unit, University of Padua, Padua, Italy
⨯
Claudia Mescoli,

Roles Resources

Affiliation Department of Medicine, DIMED, Surgical Pathology and Cytopathology Unit, University of Padua, Padua, Italy
⨯
Feng Gao,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Visualization, Writing – review & editing

Current address: Biogen, Cambridge, Massachusetts, United States of America

Affiliation Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, Cambridge, Massachusetts, United States of America
⨯
William L. Trepicchio,

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, Cambridge, Massachusetts, United States of America
⨯
Massimo Rugge

Roles Conceptualization, Investigation

Affiliation Department of Medicine, DIMED, Surgical Pathology and Cytopathology Unit, University of Padua, Padua, Italy
⨯

Consistent expression of guanylyl cyclase-C in primary and metastatic gastrointestinal cancers

Hadi Danaee,
Thea Kalebic,
Timothy Wyant,
Matteo Fassan,
Claudia Mescoli,
Feng Gao,
William L. Trepicchio,
Massimo Rugge

Published: December 19, 2017
https://doi.org/10.1371/journal.pone.0189953

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Colorectal cancer
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Gastric cancer
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Esophageal cancer
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Cytoplasmic staining
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Protein expression
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