Integrative network analysis highlights biological processes underlying GLP-1 stimulated insulin secretion: A DIRECT study

• Valborg Gudmundsdottir,

  Roles Conceptualization, Formal analysis, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Bio and Health Informatics, Technical University of Denmark, Kongens Lyngby, Denmark

  http://orcid.org/0000-0002-7459-1603

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• Helle Krogh Pedersen,

  Roles Conceptualization, Formal analysis, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Bio and Health Informatics, Technical University of Denmark, Kongens Lyngby, Denmark

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• Karla Viviani Allebrandt,

  Roles Formal analysis, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Translational Bioinformatics, R&D Operations, Sanofi-Aventis Deutschland GmbH, Industriepark Höchst, Frankfurt, Germany

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• Caroline Brorsson,

  Roles Conceptualization, Project administration, Writing – original draft, Writing – review & editing

  Affiliation Department of Bio and Health Informatics, Technical University of Denmark, Kongens Lyngby, Denmark

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• Nienke van Leeuwen,

  Roles Data curation, Formal analysis, Resources, Writing – review & editing

  Affiliation Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands

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• Karina Banasik,

  Roles Data curation, Formal analysis, Investigation, Writing – review & editing

  Affiliations Novo Nordisk Foundation Center for Protein Research, Disease Systems Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, Wellcome Trust Center for Human Genetics, University of Oxford, Oxford, United Kingdom

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• Anubha Mahajan,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Oxford NIHR Biomedical Research Center, Oxford, United Kingdom

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• Christopher J. Groves,

  Roles Conceptualization, Investigation, Writing – review & editing

  Affiliation Oxford Center for Diabetes Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom

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• Martijn van de Bunt,

  Roles Data curation, Writing – review & editing

  Affiliations Oxford NIHR Biomedical Research Center, Oxford, United Kingdom, Oxford Center for Diabetes Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom

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• Adem Y. Dawed,

  Roles Investigation, Validation, Writing – review & editing

  Affiliation Division of Molecular & Clinical Medicine, School of Medicine, University of Dundee, Dundee, United Kingdom

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• Andreas Fritsche,

  Roles Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tübingen, Member of the German Centre for Diabetes Research (DZD), Tübingen, Germany

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• Harald Staiger,

  Roles Investigation, Resources, Validation, Writing – review & editing

  Affiliation Institute of Pharmaceutical Sciences, Department of Pharmacy and Biochemistry, Eberhard Karls University, Tübingen, Germany

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• Annemarie M. C. Simonis-Bik,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Department of Internal Medicine, Diabetes Center and Endocrinology, VU University Medical Center, Amsterdam, The Netherlands

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• Joris Deelen,

  Roles Formal analysis, Software, Writing – review & editing

  Affiliations Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands, Max Planck Institute for Biology of Ageing, Cologne, Germany

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• Mark H. H. Kramer,

  Roles Resources, Writing – review & editing

  Affiliation Department of Internal Medicine, Diabetes Center and Endocrinology, VU University Medical Center, Amsterdam, The Netherlands

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• Axel Dietrich,

  Roles Formal analysis, Writing – review & editing

  Affiliation Department of Translational Bioinformatics, R&D Operations, Sanofi-Aventis Deutschland GmbH, Industriepark Höchst, Frankfurt, Germany

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• Thomas Hübschle,

  Roles Investigation, Writing – review & editing

  Affiliation Department GI Endocrinology, R&D Diabetes Division, Sanofi-Aventis Deutschland GmbH, Industriepark Höchst, Frankfurt, Germany

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• Gonneke Willemsen,

  Roles Investigation, Methodology, Resources, Writing – review & editing

  Affiliation Department of Biological Psychology, Vrije Universiteit and the EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands

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• Hans-Ulrich Häring,

  Roles Methodology, Resources, Validation, Writing – review & editing

  Affiliation Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tübingen, Member of the German Centre for Diabetes Research (DZD), Tübingen, Germany

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• Eco J. C. de Geus,

  Roles Investigation, Methodology, Resources, Writing – review & editing

  Affiliations Department of Biological Psychology, Vrije Universiteit and the EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands, Netherlands Consortium for Healthy Aging, Leiden, The Netherlands

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• Dorret I. Boomsma,

  Roles Investigation, Methodology, Resources, Writing – review & editing

  Affiliation Department of Biological Psychology, Vrije Universiteit and the EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands

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• Elisabeth M. W. Eekhoff,

  Roles Data curation, Investigation, Methodology, Resources, Writing – review & editing

  Affiliation Department of Internal Medicine, Diabetes Center and Endocrinology, VU University Medical Center, Amsterdam, The Netherlands

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• Jorge Ferrer,

  Roles Conceptualization, Funding acquisition, Resources, Writing – review & editing

  Affiliations Section of Epigenomics and Disease, Department of Medicine, Imperial College London, London, United Kingdom, Genomic Programming of Beta Cells Laboratory, Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Barcelona, Spain, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain

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• Mark I. McCarthy,

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  Affiliations Wellcome Trust Center for Human Genetics, University of Oxford, Oxford, United Kingdom, Oxford NIHR Biomedical Research Center, Oxford, United Kingdom, Oxford Center for Diabetes Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom

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• Ewan R. Pearson,

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

  Affiliation Division of Molecular & Clinical Medicine, School of Medicine, University of Dundee, Dundee, United Kingdom

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• Ramneek Gupta,

  Roles Conceptualization, Supervision, Writing – review & editing

  Affiliation Department of Bio and Health Informatics, Technical University of Denmark, Kongens Lyngby, Denmark

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• Søren Brunak,

  Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Department of Bio and Health Informatics, Technical University of Denmark, Kongens Lyngby, Denmark, Novo Nordisk Foundation Center for Protein Research, Disease Systems Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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•  [ ... ],
• Leen M. ‘t Hart

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: lmthart@lumc.nl

  Affiliations Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands

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