The natural compound Jatrophone interferes with Wnt/β-catenin signaling and inhibits proliferation and EMT in human triple-negative breast cancer

• Iram Fatima ,

  Contributed equally to this work with: Iram Fatima, Ikbale El-Ayachi

  Roles Conceptualization, Data curation, Formal analysis, Writing – original draft, Writing – review & editing

  Affiliation Department of Medicine, College of Medicine at UTHSC, UTHSC Center for Cancer Research Memphis, Tennessee, United States of America

  ⨯
• Ikbale El-Ayachi ,

  Contributed equally to this work with: Iram Fatima, Ikbale El-Ayachi

  Roles Conceptualization, Data curation, Formal analysis, Writing – original draft, Writing – review & editing

  Affiliation Department of Medicine, College of Medicine at UTHSC, UTHSC Center for Cancer Research Memphis, Tennessee, United States of America

  ⨯
• Ling Taotao,

  Roles Conceptualization, Investigation

  Affiliation Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

  ⨯
• M. Angeles Lillo,

  Roles Data curation

  Affiliation Department of Orthopaedic Surgery and Biomedical Engineering, UTHSC, Center for Cancer Research, UTHSC, Memphis, Tennessee, United States of America

  ⨯
• Raya Krutilina,

  Roles Data curation, Investigation

  Affiliation Department of Pathology and Laboratory Medicine, College of Medicine at UTHSC, UTHSC Center for Cancer Research Memphis, Tennessee, United States of America

  ⨯
• Tiffany N. Seagroves,

  Roles Formal analysis, Resources, Supervision, Writing – review & editing

  Affiliation Department of Pathology and Laboratory Medicine, College of Medicine at UTHSC, UTHSC Center for Cancer Research Memphis, Tennessee, United States of America

  ⨯
• Tomasz W. Radaszkiewicz,

  Roles Data curation

  Affiliation Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic

  ⨯
• Miroslav Hutnan,

  Roles Data curation

  Affiliation Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic

  ⨯
• Vitezslav Bryja,

  Roles Conceptualization, Formal analysis, Resources, Supervision, Writing – review & editing

  Affiliation Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic

  ⨯
• Susan A. Krum,

  Roles Conceptualization, Data curation, Formal analysis, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Department of Orthopaedic Surgery and Biomedical Engineering, UTHSC, Center for Cancer Research, UTHSC, Memphis, Tennessee, United States of America

  ⨯
• Fatima Rivas,

  Roles Conceptualization, Data curation, Formal analysis, Supervision, Writing – review & editing

  Affiliation Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

  ⨯
• Gustavo A. Miranda-Carboni

  Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: GMirand1@UTHSC.edu

  Affiliation Department of Medicine, College of Medicine at UTHSC, UTHSC Center for Cancer Research Memphis, Tennessee, United States of America

  http://orcid.org/0000-0003-1313-9207

  ⨯