Cardiac-specific ablation of the E3 ubiquitin ligase Mdm2 leads to oxidative stress, broad mitochondrial deficiency and early death

• Ludger Hauck,

  Roles Conceptualization, Formal analysis, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Toronto General Research Institute, Toronto, Ontario, Canada

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• Shanna Stanley-Hasnain,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliation Toronto General Research Institute, Toronto, Ontario, Canada

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• Amelia Fung,

  Roles Data curation, Investigation, Methodology, Writing – review & editing

  Affiliation Toronto General Research Institute, Toronto, Ontario, Canada

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• Daniela Grothe,

  Roles Data curation, Investigation, Methodology, Project administration, Supervision, Writing – review & editing

  Affiliation Toronto General Research Institute, Toronto, Ontario, Canada

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• Vivek Rao,

  Roles Methodology, Visualization, Writing – review & editing

  Affiliation Division of Cardiovascular Surgery, UHN, Toronto, Ontario, Canada

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• Tak W. Mak,

  Roles Conceptualization, Validation, Writing – review & editing

  Affiliation Campbell Family Cancer Research Institute, Princess Margaret Hospital, Toronto, Ontario, Canada

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• Filio Billia

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: phyllis.billia@uhn.ca

  Affiliations Toronto General Research Institute, Toronto, Ontario, Canada, Division of Cardiology, University Health Network (UHN), Toronto, Ontario, Canada, Heart and Stroke Richard Lewar Centre of Excellence, University of Toronto, Toronto, Ontario, Canada, Institute of Medical Science, University of Toronto, Toronto, Ontario Canada

  http://orcid.org/0000-0002-2824-1215

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