Active site-targeted covalent irreversible inhibitors of USP7 impair the functions of Foxp3+ T-regulatory cells by promoting ubiquitination of Tip60

• Feng Wang,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft

  Affiliation Progenra Inc, Malvern, Pennsylvania, United States of America

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• Liqing Wang,

  Roles Methodology

  Affiliation Division of Transplant Immunology, Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Jian Wu,

  Roles Methodology

  Affiliation Progenra Inc, Malvern, Pennsylvania, United States of America

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• Ivan Sokirniy,

  Roles Methodology

  Affiliation Progenra Inc, Malvern, Pennsylvania, United States of America

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• Phuong Nguyen,

  Roles Methodology

  Affiliation Progenra Inc, Malvern, Pennsylvania, United States of America

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• Thomas Bregnard,

  Roles Methodology, Writing – review & editing

  Affiliation Department of Molecular Biology and Biophysics, UCONN Health, Farmington, Connecticut, United States of America

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• Joseph Weinstock,

  Roles Funding acquisition, Supervision

  Affiliation Progenra Inc, Malvern, Pennsylvania, United States of America

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• Michael Mattern,

  Roles Funding acquisition, Project administration, Resources, Writing – review & editing

  Affiliation Progenra Inc, Malvern, Pennsylvania, United States of America

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• Irina Bezsonova,

  Roles Formal analysis, Funding acquisition, Project administration, Supervision, Writing – review & editing

  Affiliation Department of Molecular Biology and Biophysics, UCONN Health, Farmington, Connecticut, United States of America

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• Wayne W. Hancock,

  Roles Formal analysis, Funding acquisition, Project administration, Supervision, Writing – review & editing

  Affiliation Division of Transplant Immunology, Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Suresh Kumar

  Roles Conceptualization, Data curation, Formal analysis, Project administration, Supervision, Writing – review & editing

  * E-mail: kumar@progenra.com

  Affiliation Progenra Inc, Malvern, Pennsylvania, United States of America

  http://orcid.org/0000-0002-1940-772X

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