Crystal structures of H-2Db in complex with the LCMV-derived peptides GP92 and GP392 explain pleiotropic effects of glycosylation on antigen presentation and immunogenicity

Ida Hafstrand; Daniel Badia-Martinez; Benjamin John Josey; Melissa Norström; Jérémie Buratto; Sara Pellegrino; Adil Doganay Duru; Tatyana Sandalova; Adnane Achour

doi:10.1371/journal.pone.0189584

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Peer-reviewed

Research Article

Crystal structures of H-2D^b in complex with the LCMV-derived peptides GP92 and GP392 explain pleiotropic effects of glycosylation on antigen presentation and immunogenicity

Ida Hafstrand ,

Roles Formal analysis, Validation, Visualization, Writing – original draft, Writing – review & editing

¶‡ These authors are co-first authors on this work.

Affiliation Science for Life Laboratory, Department of Medicine Solna, Karolinska Institutet, and Department of Infectious Diseases, Karolinska University Hospital, Solna, Stockholm, Sweden

http://orcid.org/0000-0002-1012-9532

⨯
Daniel Badia-Martinez ,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Validation

¶‡ These authors are co-first authors on this work.

Affiliation Science for Life Laboratory, Department of Medicine Solna, Karolinska Institutet, and Department of Infectious Diseases, Karolinska University Hospital, Solna, Stockholm, Sweden
⨯
Benjamin John Josey,

Roles Writing – review & editing

Affiliations NSU Cell Therapy Institute, Nova Southeastern University, Fort Lauderdale, FL, United State of America, College of Allopathic Medicine, Nova Southeastern University, Fort Lauderdale, FL, United State of America
⨯
Melissa Norström,

Roles Formal analysis, Investigation

Affiliation Science for Life Laboratory, Department of Medicine Solna, Karolinska Institutet, and Department of Infectious Diseases, Karolinska University Hospital, Solna, Stockholm, Sweden
⨯
Jérémie Buratto,

Roles Formal analysis, Validation, Writing – original draft

Affiliation Science for Life Laboratory, Department of Medicine Solna, Karolinska Institutet, and Department of Infectious Diseases, Karolinska University Hospital, Solna, Stockholm, Sweden
⨯
Sara Pellegrino,

Roles Resources

Affiliation DISFARM, Dipartimento di Scienze Farmaceutiche, Sezinone Chimica Generale e Organica, Università degli Studi, Milano, Italy
⨯
Adil Doganay Duru,

Roles Supervision, Validation, Writing – review & editing

Affiliations NSU Cell Therapy Institute, Nova Southeastern University, Fort Lauderdale, FL, United State of America, College of Allopathic Medicine, Nova Southeastern University, Fort Lauderdale, FL, United State of America
⨯
Tatyana Sandalova,

Roles Conceptualization, Formal analysis, Methodology, Supervision, Validation, Visualization, Writing – review & editing

Affiliation Science for Life Laboratory, Department of Medicine Solna, Karolinska Institutet, and Department of Infectious Diseases, Karolinska University Hospital, Solna, Stockholm, Sweden
⨯
Adnane Achour

Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – review & editing

* E-mail: adnane.achour@ki.se

Affiliation Science for Life Laboratory, Department of Medicine Solna, Karolinska Institutet, and Department of Infectious Diseases, Karolinska University Hospital, Solna, Stockholm, Sweden
⨯

Crystal structures of H-2D^b in complex with the LCMV-derived peptides GP92 and GP392 explain pleiotropic effects of glycosylation on antigen presentation and immunogenicity

Ida Hafstrand,
Daniel Badia-Martinez,
Benjamin John Josey,
Melissa Norström,
Jérémie Buratto,
Sara Pellegrino,
Adil Doganay Duru,
Tatyana Sandalova,
Adnane Achour

Published: December 18, 2017
https://doi.org/10.1371/journal.pone.0189584

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