Lithium reduces blood glucose levels, but aggravates albuminuria in BTBR-ob/ob mice

Theun de Groot; Lars Damen; Leanne Kosse; Mohammad Alsady; Rosalinda Doty; Ruben Baumgarten; Susan Sheehan; Johan van der Vlag; Ron Korstanje; Peter M. T. Deen

doi:10.1371/journal.pone.0189485

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Open Access

Peer-reviewed

Research Article

Lithium reduces blood glucose levels, but aggravates albuminuria in BTBR-ob/ob mice

Theun de Groot,

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Visualization, Writing – original draft, Writing – review & editing

Affiliations The Jackson Laboratory, Bar Harbor, Maine, United States of America, Department of Physiology, Radboud University Medical Center, Nijmegen, The Netherlands

http://orcid.org/0000-0001-5841-6461

⨯
Lars Damen,

Roles Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

Affiliation Department of Physiology, Radboud University Medical Center, Nijmegen, The Netherlands
⨯
Leanne Kosse,

Roles Formal analysis, Investigation, Writing – original draft

Affiliations The Jackson Laboratory, Bar Harbor, Maine, United States of America, Department of Physiology, Radboud University Medical Center, Nijmegen, The Netherlands
⨯
Mohammad Alsady,

Roles Formal analysis, Investigation

Affiliation Department of Physiology, Radboud University Medical Center, Nijmegen, The Netherlands
⨯
Rosalinda Doty,

Roles Formal analysis, Investigation, Methodology

Affiliation The Jackson Laboratory, Bar Harbor, Maine, United States of America
⨯
Ruben Baumgarten,

Roles Funding acquisition

Affiliation Vivium Care Group, Huizen, The Netherlands
⨯
Susan Sheehan,

Roles Formal analysis, Investigation, Methodology

Affiliation The Jackson Laboratory, Bar Harbor, Maine, United States of America
⨯
Johan van der Vlag,

Roles Supervision, Writing – review & editing

Affiliation Department of Nephrology, Radboud University Medical Center, Nijmegen, The Netherlands
⨯
Ron Korstanje ,

Contributed equally to this work with: Ron Korstanje, Peter M. T. Deen

Roles Project administration, Resources, Supervision, Writing – review & editing

Affiliation The Jackson Laboratory, Bar Harbor, Maine, United States of America
⨯
Peter M. T. Deen

Contributed equally to this work with: Ron Korstanje, Peter M. T. Deen

Roles Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: peter.deen@radboudumc.nl

Affiliation Department of Physiology, Radboud University Medical Center, Nijmegen, The Netherlands
⨯

Lithium reduces blood glucose levels, but aggravates albuminuria in BTBR-ob/ob mice

Theun de Groot,
Lars Damen,
Leanne Kosse,
Mohammad Alsady,
Rosalinda Doty,
Ruben Baumgarten,
Susan Sheehan,
Johan van der Vlag,
Ron Korstanje,
Peter M. T. Deen

Published: December 15, 2017
https://doi.org/10.1371/journal.pone.0189485

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Lithium
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Diabetes mellitus
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Kidneys
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Blood sugar
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Albumins
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Mouse models
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Glucose
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Insulin
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