Histamine Receptor 3 negatively regulates oligodendrocyte differentiation and remyelination

Yongfeng Chen; Wei Zhen; Tony Guo; Yonggang Zhao; Ailian Liu; Justin P. Rubio; David Krull; Jill C. Richardson; Hongtao Lu; Ryan Wang

doi:10.1371/journal.pone.0189380

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Open Access

Peer-reviewed

Research Article

Histamine Receptor 3 negatively regulates oligodendrocyte differentiation and remyelination

Yongfeng Chen,

Roles Data curation, Formal analysis, Visualization, Writing – review & editing

Affiliation Neuro-immunology Discovery Performance Unit, GSK, Shanghai, China
⨯
Wei Zhen,

Roles Data curation, Formal analysis, Visualization, Writing – review & editing

Affiliation RD Platform Technology & Science, GSK, Shanghai, China
⨯
Tony Guo,

Roles Data curation, Formal analysis, Visualization, Writing – review & editing

Current address: Roche Holding Ltd, Shanghai, China

Affiliation RD Platform Technology & Science, GSK, Shanghai, China
⨯
Yonggang Zhao,

Roles Conceptualization, Formal analysis, Visualization, Writing – review & editing

Current address: Suzhou Finder Therapeutics Inc., Suzhou, China

Affiliation Genetics, Projects Clinical Platforms & Sciences, GSK, Stevenage, Herts, United Kingdom
⨯
Ailian Liu,

Roles Conceptualization, Formal analysis, Methodology, Visualization, Writing – review & editing

Affiliation RD Platform Technology & Science, GSK, Shanghai, China
⨯
Justin P. Rubio,

Roles Data curation, Formal analysis, Visualization, Writing – review & editing

Current address: Department of Pathology, University of Melbourne, Melbourne, Australia

Affiliation Genetics, Projects Clinical Platforms & Sciences, GSK, Stevenage, Herts, United Kingdom
⨯
David Krull,

Roles Data curation, Formal analysis, Visualization, Writing – review & editing

Affiliation Pathology, RD Platform Technology & Science, GSK, Research Triangle Park, NC, United States of America
⨯
Jill C. Richardson,

Roles Visualization, Writing – review & editing

Current address: Neuroscience Virtual Proof of Concept Discovery Performance Unit, GSK, Stevenage, Herts, United Kingdom

Affiliation Neuroinflammation DPU, Neurosciences TAU, GSK, Stevenage, Herts, United Kingdom
⨯
Hongtao Lu,

Roles Conceptualization, Methodology, Validation, Writing – review & editing

Current address: Zai Laboratory, Inc., Pudong, Shanghai, China

Affiliation Neuro-immunology Discovery Performance Unit, GSK, Shanghai, China
⨯
Ryan Wang

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

* E-mail: ryan.r.wang@gsk.com

Affiliation Neuro-immunology Discovery Performance Unit, GSK, Shanghai, China

http://orcid.org/0000-0002-1896-994X

⨯

Histamine Receptor 3 negatively regulates oligodendrocyte differentiation and remyelination

Yongfeng Chen,
Wei Zhen,
Tony Guo,
Yonggang Zhao,
Ailian Liu,
Justin P. Rubio,
David Krull,
Jill C. Richardson,
Hongtao Lu,
Ryan Wang

Published: December 18, 2017
https://doi.org/10.1371/journal.pone.0189380

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