Docking and quantitative structure–activity relationship of bi-cyclic heteroaromatic pyridazinone and pyrazolone derivatives as phosphodiesterase 3A (PDE3A) inhibitors

• Camila Muñoz-Gutiérrez,

  Roles Formal analysis, Investigation

  Affiliation Centro de Bioinformática y Simulación Molecular (CBSM), Universidad de Talca, Talca, Chile

  ⨯
• Daniela Cáceres-Rojas,

  Roles Investigation

  Affiliation Centro de Bioinformática y Simulación Molecular (CBSM), Universidad de Talca, Talca, Chile

  ⨯
• Francisco Adasme-Carreño,

  Roles Formal analysis, Investigation

  Affiliation Centro de Bioinformática y Simulación Molecular (CBSM), Universidad de Talca, Talca, Chile

  ⨯
• Iván Palomo,

  Roles Formal analysis, Supervision

  Affiliation Platelet Research Laboratory, Department of Clinical Biochemistry and Immunohematology, Faculty of Health Sciences, Interdisciplinary Excellence Research Program on Healthy Aging (PIEI-ES), Universidad de Talca, Talca, Chile

  ⨯
• Eduardo Fuentes,

  Roles Formal analysis, Supervision

  Affiliations Platelet Research Laboratory, Department of Clinical Biochemistry and Immunohematology, Faculty of Health Sciences, Interdisciplinary Excellence Research Program on Healthy Aging (PIEI-ES), Universidad de Talca, Talca, Chile, Núcleo Científico Multidisciplinario, Universidad de Talca, Talca, Chile

  ⨯
• Julio Caballero

  Roles Conceptualization, Formal analysis, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: jcaballero@utalca.cl

  Affiliation Centro de Bioinformática y Simulación Molecular (CBSM), Universidad de Talca, Talca, Chile

  http://orcid.org/0000-0003-0182-1444

  ⨯