Altered intragenic DNA methylation of HOOK2 gene in adipose tissue from individuals with obesity and type 2 diabetes

• Sandra Rodríguez-Rodero ,

  Contributed equally to this work with: Sandra Rodríguez-Rodero, Edelmiro Menéndez-Torre

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft

  Affiliations Endocrinology and Nutrition Department, Hospital Universitario Central de Asturias (HUCA), Asturias, Spain, Cancer Epigenetics Laboratory, Institute of Oncology of Asturias (IUOPA), HUCA, Universidad de Oviedo, Asturias, Spain, Endocrinology, Nutrition, Diabetes and Obesity Unit, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Asturias, Spain

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• Edelmiro Menéndez-Torre ,

  Contributed equally to this work with: Sandra Rodríguez-Rodero, Edelmiro Menéndez-Torre

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Supervision, Writing – original draft

  Affiliations Endocrinology and Nutrition Department, Hospital Universitario Central de Asturias (HUCA), Asturias, Spain, Endocrinology, Nutrition, Diabetes and Obesity Unit, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Asturias, Spain

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• Gustavo Fernández-Bayón,

  Roles Formal analysis, Writing – original draft

  Affiliations Cancer Epigenetics Laboratory, Institute of Oncology of Asturias (IUOPA), HUCA, Universidad de Oviedo, Asturias, Spain, Endocrinology, Nutrition, Diabetes and Obesity Unit, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Asturias, Spain

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• Paula Morales-Sánchez,

  Roles Resources

  Affiliations Endocrinology and Nutrition Department, Hospital Universitario Central de Asturias (HUCA), Asturias, Spain, Cancer Epigenetics Laboratory, Institute of Oncology of Asturias (IUOPA), HUCA, Universidad de Oviedo, Asturias, Spain, Endocrinology, Nutrition, Diabetes and Obesity Unit, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Asturias, Spain

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• Lourdes Sanz,

  Roles Resources

  Affiliation Surgery Department, Hospital Universitario Central de Asturias, Asturias, Spain

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• Estrella Turienzo,

  Roles Resources

  Affiliation Surgery Department, Hospital Universitario Central de Asturias, Asturias, Spain

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• Juan José González,

  Roles Resources

  Affiliation Surgery Department, Hospital Universitario Central de Asturias, Asturias, Spain

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• Ceferino Martinez-Faedo,

  Roles Resources

  Affiliations Endocrinology and Nutrition Department, Hospital Universitario Central de Asturias (HUCA), Asturias, Spain, Endocrinology, Nutrition, Diabetes and Obesity Unit, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Asturias, Spain

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• Lorena Suarez-Gutiérrez,

  Roles Resources

  Affiliations Endocrinology and Nutrition Department, Hospital Universitario Central de Asturias (HUCA), Asturias, Spain, Endocrinology, Nutrition, Diabetes and Obesity Unit, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Asturias, Spain

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• Jessica Ares,

  Roles Resources

  Affiliations Endocrinology and Nutrition Department, Hospital Universitario Central de Asturias (HUCA), Asturias, Spain, Endocrinology, Nutrition, Diabetes and Obesity Unit, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Asturias, Spain

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• Lucia Díaz-Naya,

  Roles Resources

  Affiliations Endocrinology and Nutrition Department, Hospital Universitario Central de Asturias (HUCA), Asturias, Spain, Endocrinology, Nutrition, Diabetes and Obesity Unit, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Asturias, Spain

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• Alicia Martin-Nieto,

  Roles Resources

  Affiliations Endocrinology and Nutrition Department, Hospital Universitario Central de Asturias (HUCA), Asturias, Spain, Endocrinology, Nutrition, Diabetes and Obesity Unit, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Asturias, Spain

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• Juan L. Fernández-Morera,

  Roles Funding acquisition, Resources

  Affiliations Endocrinology and Nutrition Department, Hospital Universitario Central de Asturias (HUCA), Asturias, Spain, Endocrinology, Nutrition, Diabetes and Obesity Unit, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Asturias, Spain

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• Mario F. Fraga ,

  Roles Supervision, Writing – review & editing

  ¶‡ These authors also contributed equally to this work.

  Affiliations Endocrinology, Nutrition, Diabetes and Obesity Unit, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Asturias, Spain, Centro de Investigación en Nanomateriales y Nanotecnología (CINN), El Entrego, Asturias, Spain

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• Elías Delgado-Álvarez

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  * E-mail: eliasdelga@gmail.com, delgadoelias@uniovi.es

  ¶‡ These authors also contributed equally to this work.

  Affiliations Endocrinology and Nutrition Department, Hospital Universitario Central de Asturias (HUCA), Asturias, Spain, Endocrinology, Nutrition, Diabetes and Obesity Unit, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Asturias, Spain, Medicine Department, Universidad de Oviedo, Asturias, Spain

  http://orcid.org/0000-0001-6114-9712

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