The acute glucose lowering effect of specific GPR120 activation in mice is mainly driven by glucagon-like peptide 1

Linda Sundström; Susanna Myhre; Monika Sundqvist; Andrea Ahnmark; William McCoull; Piotr Raubo; Sam D. Groombridge; Magnus Polla; Ann-Christin Nyström; Lisbeth Kristensson; Mats Någård; Maria Sörhede Winzell

doi:10.1371/journal.pone.0189060

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Open Access

Peer-reviewed

Research Article

The acute glucose lowering effect of specific GPR120 activation in mice is mainly driven by glucagon-like peptide 1

Linda Sundström ,

Contributed equally to this work with: Linda Sundström, Susanna Myhre

Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

Affiliation Discovery Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden
⨯
Susanna Myhre ,

Contributed equally to this work with: Linda Sundström, Susanna Myhre

Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

Affiliation Cardiovascular and Metabolic Diseases, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden
⨯
Monika Sundqvist,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

Affiliation Cardiovascular and Metabolic Diseases, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden
⨯
Andrea Ahnmark,

Roles Investigation, Methodology

Affiliation Cardiovascular and Metabolic Diseases, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden
⨯
William McCoull,

Roles Conceptualization, Investigation, Methodology

Affiliation Medicinal Chemistry, IMED Biotech Unit, AstraZeneca, Alderley Park, United Kingdom
⨯
Piotr Raubo,

Roles Investigation, Methodology

Affiliation Medicinal Chemistry, IMED Biotech Unit, AstraZeneca, Alderley Park, United Kingdom
⨯
Sam D. Groombridge,

Roles Investigation, Methodology

Affiliation Medicinal Chemistry, IMED Biotech Unit, AstraZeneca, Alderley Park, United Kingdom
⨯
Magnus Polla,

Roles Investigation, Methodology

Affiliation Cardiovascular and Metabolic Diseases, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden
⨯
Ann-Christin Nyström,

Roles Investigation, Methodology

Affiliation Cardiovascular and Metabolic Diseases, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden
⨯
Lisbeth Kristensson,

Roles Investigation, Methodology

Affiliation Discovery Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden
⨯
Mats Någård,

Roles Conceptualization, Project administration, Writing – review & editing

Affiliation Cardiovascular and Metabolic Diseases, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden
⨯
Maria Sörhede Winzell

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

* E-mail: Maria.Sorhede-Winzell@astrazeneca.com

Affiliation Cardiovascular and Metabolic Diseases, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden

http://orcid.org/0000-0003-3125-4858

⨯

The acute glucose lowering effect of specific GPR120 activation in mice is mainly driven by glucagon-like peptide 1

Linda Sundström,
Susanna Myhre,
Monika Sundqvist,
Andrea Ahnmark,
William McCoull,
Piotr Raubo,
Sam D. Groombridge,
Magnus Polla,
Ann-Christin Nyström,
Lisbeth Kristensson

Published: December 5, 2017
https://doi.org/10.1371/journal.pone.0189060

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