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Open Access
Peer-reviewed
Research Article
Substitutions of PrP N-terminal histidine residues modulate scrapie disease pathogenesis and incubation time in transgenic mice
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Sabina Eigenbrod,
Roles Investigation
Current address: Servier Deutschland GmbH, Munich, Germany
Affiliation Center for Neuropathology and Prion Research, Ludwig Maximilians University, Munich, Germany
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Petra Frick ,
Roles Investigation, Writing – original draft, Writing – review & editing
* E-mail: petra.frick@dzne.de
Current address: German Center for Neurodegenerative Diseases, Tübingen, Germany
Affiliation Center for Neuropathology and Prion Research, Ludwig Maximilians University, Munich, Germany
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Uwe Bertsch,
Roles Formal analysis, Investigation
Current address: Louisenlund School, Güby, Germany
Affiliation Center for Neuropathology and Prion Research, Ludwig Maximilians University, Munich, Germany
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Gerda Mitteregger-Kretzschmar,
Roles Investigation, Writing – original draft, Writing – review & editing
Affiliation Center for Neuropathology and Prion Research, Ludwig Maximilians University, Munich, Germany
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Janina Mielke,
Roles Investigation
Affiliation Center for Neuropathology and Prion Research, Ludwig Maximilians University, Munich, Germany
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Marko Maringer,
Roles Investigation
Current address: MFD Diagnostic GmbH, Wendelsheim, Germany
Affiliation Center for Neuropathology and Prion Research, Ludwig Maximilians University, Munich, Germany
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Niklas Piening,
Roles Investigation
Current address: BASF SE, Ludwigshafen, Germany
Affiliation Center for Neuropathology and Prion Research, Ludwig Maximilians University, Munich, Germany
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Alexander Hepp,
Roles Investigation
Current address: Klenze Secondary School Munich, Munich, Germany
Affiliation Center for Neuropathology and Prion Research, Ludwig Maximilians University, Munich, Germany
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Nathalie Daude,
Roles Investigation, Writing – review & editing
Affiliation Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada
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Otto Windl,
Roles Writing – review & editing
Affiliation Center for Neuropathology and Prion Research, Ludwig Maximilians University, Munich, Germany
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Johannes Levin,
Roles Investigation
Current address: Department of Neurology, University Hospital Munich, Munich, Germany
Affiliation Center for Neuropathology and Prion Research, Ludwig Maximilians University, Munich, Germany
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Armin Giese,
Roles Conceptualization, Investigation
Affiliation Center for Neuropathology and Prion Research, Ludwig Maximilians University, Munich, Germany
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Vignesh Sakthivelu,
Roles Investigation
Current address: Present address, Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases CECAD, University Cologne, Cologne, Germany
Affiliation Department of Metabolic Biochemistry/Neurobiochemistry, Adolf Butenandt Institute, Ludwig Maximilians University, Munich, Germany
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Jörg Tatzelt,
Roles Investigation
Current address: Department of Biochemistry of Neurodegenerative Diseases, Ruhr University Bochum, Bochum, Germany
Affiliation Department of Metabolic Biochemistry/Neurobiochemistry, Adolf Butenandt Institute, Ludwig Maximilians University, Munich, Germany
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Hans Kretzschmar †,
† Deceased.
Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft
Affiliation Center for Neuropathology and Prion Research, Ludwig Maximilians University, Munich, Germany
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David Westaway
Roles Writing – review & editing
Affiliation Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada
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Substitutions of PrP N-terminal histidine residues modulate scrapie disease pathogenesis and incubation time in transgenic mice
- Sabina Eigenbrod,
- Petra Frick,
- Uwe Bertsch,
- Gerda Mitteregger-Kretzschmar,
- Janina Mielke,
- Marko Maringer,
- Niklas Piening,
- Alexander Hepp,
- Nathalie Daude,
- Otto Windl
- Published: December 8, 2017
- https://doi.org/10.1371/journal.pone.0188989