Transplantation of canine olfactory ensheathing cells producing chondroitinase ABC promotes chondroitin sulphate proteoglycan digestion and axonal sprouting following spinal cord injury

Darren Carwardine; Jonathan Prager; Jacob Neeves; Elizabeth M. Muir; James Uney; Nicolas Granger; Liang-Fong Wong

doi:10.1371/journal.pone.0188967

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Peer-reviewed

Research Article

Transplantation of canine olfactory ensheathing cells producing chondroitinase ABC promotes chondroitin sulphate proteoglycan digestion and axonal sprouting following spinal cord injury

Darren Carwardine,

Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation School of Veterinary Sciences, University of Bristol, Bristol, United Kingdom
⨯
Jonathan Prager,

Roles Investigation, Validation, Writing – review & editing

Affiliation School of Veterinary Sciences, University of Bristol, Bristol, United Kingdom
⨯
Jacob Neeves,

Roles Investigation, Writing – review & editing

Affiliation School of Veterinary Sciences, University of Bristol, Bristol, United Kingdom
⨯
Elizabeth M. Muir,

Roles Resources, Writing – review & editing

Affiliation Department of Physiology Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom
⨯
James Uney,

Roles Resources, Writing – review & editing

Affiliation Bristol Medical School, University of Bristol, Bristol, United Kingdom
⨯
Nicolas Granger,

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – review & editing

Current address: The Royal Veterinary College, Hatfield, Hertfordshire and Cave Veterinary Specialists, George’s Farm Nr Wellington, West Buckland, Wellington, United Kingdom

Affiliation School of Veterinary Sciences, University of Bristol, Bristol, United Kingdom
⨯
Liang-Fong Wong

Roles Conceptualization, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing

* E-mail: l.wong@bristol.ac.uk

Affiliation Bristol Medical School, University of Bristol, Bristol, United Kingdom

http://orcid.org/0000-0003-4348-698X

⨯

Transplantation of canine olfactory ensheathing cells producing chondroitinase ABC promotes chondroitin sulphate proteoglycan digestion and axonal sprouting following spinal cord injury

Darren Carwardine,
Jonathan Prager,
Jacob Neeves,
Elizabeth M. Muir,
James Uney,
Nicolas Granger,
Liang-Fong Wong

Published: December 11, 2017
https://doi.org/10.1371/journal.pone.0188967

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Axons
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Spinal cord injury
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Spinal cord
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Cell transplantation
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Schwann cells
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Transplant rejection
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Central nervous system
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Proteoglycans
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