Measurements of 6-thioguanine nucleotide levels with TPMT and NUDT15 genotyping in patients with Crohn’s disease

Ji Hyeon Lee; Tae Jun Kim; Eun Ran Kim; Sung Noh Hong; Dong Kyung Chang; Li-Hwa Choi; Hye In Woo; Soo-Youn Lee; Young-Ho Kim

doi:10.1371/journal.pone.0188925

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Open Access

Peer-reviewed

Research Article

Measurements of 6-thioguanine nucleotide levels with TPMT and NUDT15 genotyping in patients with Crohn’s disease

Ji Hyeon Lee ,

Contributed equally to this work with: Ji Hyeon Lee, Tae Jun Kim

Roles Data curation, Formal analysis

Affiliation Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
⨯
Tae Jun Kim ,

Contributed equally to this work with: Ji Hyeon Lee, Tae Jun Kim

Roles Data curation, Formal analysis, Writing – original draft

Affiliation Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
⨯
Eun Ran Kim,

Roles Data curation, Formal analysis, Methodology

Affiliation Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
⨯
Sung Noh Hong,

Roles Formal analysis, Validation

Affiliation Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
⨯
Dong Kyung Chang,

Roles Methodology, Supervision, Validation

Affiliation Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
⨯
Li-Hwa Choi,

Roles Formal analysis, Methodology

Affiliations Department of Laboratory Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea, Department of Laboratory Medicine, Green Cross Laboratories, Yongin, Gyeonggi, Republic of Korea
⨯
Hye In Woo,

Roles Formal analysis, Investigation, Methodology

Affiliation Department of Laboratory Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea
⨯
Soo-Youn Lee ,

Roles Conceptualization, Methodology, Supervision, Validation

* E-mail: bowelkim@gmail.com (YK); suddenbz@skku.edu (SL)

Affiliation Department of Laboratory Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
⨯
Young-Ho Kim

Roles Conceptualization, Funding acquisition, Resources, Supervision

* E-mail: bowelkim@gmail.com (YK); suddenbz@skku.edu (SL)

Affiliation Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
⨯

Measurements of 6-thioguanine nucleotide levels with TPMT and NUDT15 genotyping in patients with Crohn’s disease

Ji Hyeon Lee,
Tae Jun Kim,
Eun Ran Kim,
Sung Noh Hong,
Dong Kyung Chang,
Li-Hwa Choi,
Hye In Woo,
Soo-Youn Lee,
Young-Ho Kim

Published: December 5, 2017
https://doi.org/10.1371/journal.pone.0188925

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Metabolites
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Variant genotypes
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Crohn's disease
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C-reactive proteins
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Nucleotides
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Homozygosity
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