The tumor suppressor phosphatase PP2A-B56α regulates stemness and promotes the initiation of malignancies in a novel murine model

• Mahnaz Janghorban,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon, United States of America

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• Ellen M. Langer ,

  Contributed equally to this work with: Ellen M. Langer, Xiaoyan Wang

  Roles Formal analysis, Resources, Software, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon, United States of America

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• Xiaoyan Wang ,

  Contributed equally to this work with: Ellen M. Langer, Xiaoyan Wang

  Roles Formal analysis, Methodology, Validation

  Affiliation Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon, United States of America

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• Derek Zachman,

  Roles Conceptualization, Data curation, Formal analysis, Methodology

  Affiliation Papé Family Pediatric Research Institute, Oregon Stem Cell Center, Department of Pediatrics, Portland, Oregon, United States of America

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• Colin J. Daniel,

  Roles Data curation, Validation, Writing – review & editing

  Affiliation Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon, United States of America

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• Jody Hooper,

  Roles Conceptualization, Formal analysis

  Affiliation Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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• William H. Fleming,

  Roles Resources

  Affiliations Papé Family Pediatric Research Institute, Oregon Stem Cell Center, Department of Pediatrics, Portland, Oregon, United States of America, Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, United States of America

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• Anupriya Agarwal,

  Roles Conceptualization, Data curation, Resources, Supervision, Writing – review & editing

  Affiliations Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, United States of America, Division of Hematology & Medical Oncology, Oregon Health & Science University, Portland, Oregon, United States of America

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• Rosalie C. Sears

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: searsr@ohsu.edu

  Affiliations Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon, United States of America, Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, United States of America, Brenden-Colson Center for Pancreatic Care, Oregon Health and Science University, Portland, Oregon, United States of America

  http://orcid.org/0000-0003-1558-2413

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