Inferior immunogenicity and efficacy of respiratory syncytial virus fusion protein-based subunit vaccine candidates in aged versus young mice

Corinne Cayatte; Angie Snell Bennett; Gaurav Manohar Rajani; Leigh Hostetler; Sean K. Maynard; Michelle Lazzaro; Patrick McTamney; Kuishu Ren; Terrence O’Day; Michael P. McCarthy; Kirsten Schneider-Ohrum

doi:10.1371/journal.pone.0188708

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Open Access

Peer-reviewed

Research Article

Inferior immunogenicity and efficacy of respiratory syncytial virus fusion protein-based subunit vaccine candidates in aged versus young mice

Corinne Cayatte ,

Roles Conceptualization, Investigation, Writing – original draft

* E-mail: cayattec@medimmune.com

Affiliation Department of Infectious Diseases/Vaccines, MedImmune, Gaithersburg, Maryland, United States of America

http://orcid.org/0000-0002-0022-4384

⨯
Angie Snell Bennett,

Roles Investigation

Affiliation Department of Infectious Diseases/Vaccines, MedImmune, Gaithersburg, Maryland, United States of America

http://orcid.org/0000-0001-6815-1196

⨯
Gaurav Manohar Rajani,

Roles Investigation

Affiliation Department of Infectious Diseases/Vaccines, MedImmune, Gaithersburg, Maryland, United States of America

http://orcid.org/0000-0002-9827-8304

⨯
Leigh Hostetler,

Roles Investigation

Affiliation Laboratory Animal Resources, MedImmune, Gaithersburg, Maryland, United States of America
⨯
Sean K. Maynard,

Roles Investigation

Affiliation Department of Infectious Diseases/Vaccines, MedImmune, Gaithersburg, Maryland, United States of America

http://orcid.org/0000-0002-0953-4362

⨯
Michelle Lazzaro,

Roles Investigation

Affiliation Department of Infectious Diseases/Vaccines, MedImmune, Gaithersburg, Maryland, United States of America
⨯
Patrick McTamney,

Roles Investigation

Affiliation Department of Infectious Diseases/Vaccines, MedImmune, Gaithersburg, Maryland, United States of America
⨯
Kuishu Ren,

Roles Investigation

Affiliation Department of Infectious Diseases/Vaccines, MedImmune, Gaithersburg, Maryland, United States of America
⨯
Terrence O’Day,

Roles Formal analysis

Affiliation Department of Statistical Sciences, MedImmune, Gaithersburg, Maryland, United States of America
⨯
Michael P. McCarthy,

Roles Supervision, Writing – review & editing

Affiliation Department of Infectious Diseases/Vaccines, MedImmune, Gaithersburg, Maryland, United States of America
⨯
Kirsten Schneider-Ohrum

Roles Conceptualization, Investigation, Supervision, Writing – original draft

Current address: Discovery Performance Unit, GlaxoSmithKline Vaccines, Rockville, Maryland, United States of America

Affiliation Department of Infectious Diseases/Vaccines, MedImmune, Gaithersburg, Maryland, United States of America

http://orcid.org/0000-0002-0618-9196

⨯

Inferior immunogenicity and efficacy of respiratory syncytial virus fusion protein-based subunit vaccine candidates in aged versus young mice

Corinne Cayatte,
Angie Snell Bennett,
Gaurav Manohar Rajani,
Leigh Hostetler,
Sean K. Maynard,
Michelle Lazzaro,
Patrick McTamney,
Kuishu Ren,
Terrence O’Day,
Michael P. McCarthy

Published: November 28, 2017
https://doi.org/10.1371/journal.pone.0188708

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