Type I interferon signaling restrains IL-10R+ colonic macrophages and dendritic cells and leads to more severe Salmonella colitis

Kailyn L. Stefan; Avner Fink; Neeraj K. Surana; Dennis L. Kasper; Suryasarathi Dasgupta

doi:10.1371/journal.pone.0188600

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Open Access

Peer-reviewed

Research Article

Type I interferon signaling restrains IL-10R⁺ colonic macrophages and dendritic cells and leads to more severe Salmonella colitis

Kailyn L. Stefan ,

Contributed equally to this work with: Kailyn L. Stefan, Avner Fink

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Avner Fink ,

Contributed equally to this work with: Kailyn L. Stefan, Avner Fink

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Current address: Lautenberg Center for Immunology, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.

Affiliation Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Neeraj K. Surana,

Roles Conceptualization, Data curation, Writing – review & editing

Affiliations Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States of America, Division of Infectious Diseases, Department of Medicine, Boston Children’s Hospital, Boston, Massachusetts, United States of America
⨯
Dennis L. Kasper,

Roles Conceptualization, Funding acquisition, Project administration, Resources, Writing – review & editing

Affiliation Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Suryasarathi Dasgupta

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: Surya.Dasgupta@gmail.com, Suryasarathi_Dasgupta@hms.harvard.edu

Current address: Division of Immunology, Takeda California Inc., San Diego, California, United States of America.

Affiliation Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States of America

http://orcid.org/0000-0003-1421-9559

⨯

Type I interferon signaling restrains IL-10R⁺ colonic macrophages and dendritic cells and leads to more severe Salmonella colitis

Kailyn L. Stefan,
Avner Fink,
Neeraj K. Surana,
Dennis L. Kasper,
Suryasarathi Dasgupta

Published: November 30, 2017
https://doi.org/10.1371/journal.pone.0188600

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