Restoration of the prolyl-hydroxylase domain protein-3 oxygen-sensing mechanism is responsible for regulation of HIF2α expression and induction of sensitivity of myeloma cells to hypoxia-mediated apoptosis

Gilberto Gastelum; Aleksandra Poteshkina; Mysore Veena; Edgar Artiga; Geraldine Weckstein; Patrick Frost

doi:10.1371/journal.pone.0188438

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Open Access

Peer-reviewed

Research Article

Restoration of the prolyl-hydroxylase domain protein-3 oxygen-sensing mechanism is responsible for regulation of HIF2α expression and induction of sensitivity of myeloma cells to hypoxia-mediated apoptosis

Gilberto Gastelum,

Roles Data curation, Formal analysis

Affiliation Department of Hematology/Oncology, Greater Los Angeles Veteran Administration Healthcare System, Los Angeles, California, United States of America
⨯
Aleksandra Poteshkina,

Roles Data curation, Formal analysis

Affiliation Department of Hematology/Oncology, Greater Los Angeles Veteran Administration Healthcare System, Los Angeles, California, United States of America
⨯
Mysore Veena,

Roles Conceptualization, Data curation, Formal analysis

Affiliations Department of Hematology/Oncology, Greater Los Angeles Veteran Administration Healthcare System, Los Angeles, California, United States of America, Department of Hematology/Oncology, University of California, Los Angeles, Los Angeles, California, United States of America
⨯
Edgar Artiga,

Roles Data curation

Affiliation Department of Hematology/Oncology, Greater Los Angeles Veteran Administration Healthcare System, Los Angeles, California, United States of America
⨯
Geraldine Weckstein,

Roles Data curation

Affiliation Department of Hematology/Oncology, Greater Los Angeles Veteran Administration Healthcare System, Los Angeles, California, United States of America
⨯
Patrick Frost

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: Patrick.Frost@va.gov

Affiliations Department of Hematology/Oncology, Greater Los Angeles Veteran Administration Healthcare System, Los Angeles, California, United States of America, Department of Hematology/Oncology, University of California, Los Angeles, Los Angeles, California, United States of America

http://orcid.org/0000-0003-3348-5983

⨯

Restoration of the prolyl-hydroxylase domain protein-3 oxygen-sensing mechanism is responsible for regulation of HIF2α expression and induction of sensitivity of myeloma cells to hypoxia-mediated apoptosis

Gilberto Gastelum,
Aleksandra Poteshkina,
Mysore Veena,
Edgar Artiga,
Geraldine Weckstein,
Patrick Frost

Published: December 5, 2017
https://doi.org/10.1371/journal.pone.0188438

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Small interfering RNA
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DNA methylation
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