A common mechanism by which type 2A von Willebrand disease mutations enhance ADAMTS13 proteolysis revealed with a von Willebrand factor A2 domain FRET construct

• Christopher J. Lynch,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Writing – original draft, Writing – review & editing

  Current address: RDM Division of Cardiovascular Medicine and Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, United Kingdom.

  Affiliation Department of Medicine, Centre for Haematology, Imperial College London, United Kingdom

  http://orcid.org/0000-0002-4534-4865

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• Adam D. Cawte,

  Roles Methodology, Writing – review & editing

  Affiliations Department of Medicine, Molecular Virology, Imperial College, London, United Kingdom, MRC London Institute of Medical Science, Single-Molecule Imaging Group, Imperial College, London, United Kingdom

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• Carolyn M. Millar,

  Roles Resources, Writing – review & editing

  Affiliations Department of Medicine, Centre for Haematology, Imperial College London, United Kingdom, Imperial College Healthcare NHS Trust, Du Cane Road, London, United Kingdom

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• David Rueda,

  Roles Methodology, Resources, Supervision, Writing – review & editing

  Affiliations Department of Medicine, Molecular Virology, Imperial College, London, United Kingdom, MRC London Institute of Medical Science, Single-Molecule Imaging Group, Imperial College, London, United Kingdom

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• David A. Lane

  Roles Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: d.lane@imperial.ac.uk

  Affiliation Department of Medicine, Centre for Haematology, Imperial College London, United Kingdom

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