ALC1/CHD1L, a chromatin-remodeling enzyme, is required for efficient base excision repair

• Masataka Tsuda ,

  Contributed equally to this work with: Masataka Tsuda, Kosai Cho

  Roles Investigation, Writing – original draft

  Affiliation Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Yoshidakonoe, Sakyo-ku, Kyoto, Japan

  ⨯
• Kosai Cho ,

  Contributed equally to this work with: Masataka Tsuda, Kosai Cho

  Roles Investigation

  Affiliations Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Yoshidakonoe, Sakyo-ku, Kyoto, Japan, Department of Primary Care and Emergency Medicine, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan

  ⨯
• Masato Ooka,

  Roles Investigation

  Affiliation Department of Chemistry, Tokyo Metropolitan University, Minami-Osawa, Hachioji- shi, Tokyo, Japan

  ⨯
• Naoto Shimizu,

  Roles Investigation

  Affiliation Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Yoshidakonoe, Sakyo-ku, Kyoto, Japan

  ⨯
• Reiko Watanabe,

  Roles Investigation

  Current address: National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan

  Affiliation Division of Dynamic Proteome, Institute of Development, Aging and Cancer, Tohoku University, Seiryomachi 4–1, Aobaku, Sendai, Japan

  ⨯
• Akira Yasui,

  Roles Data curation

  Affiliation Division of Dynamic Proteome, Institute of Development, Aging and Cancer, Tohoku University, Seiryomachi 4–1, Aobaku, Sendai, Japan

  ⨯
• Yuka Nakazawa,

  Roles Investigation

  Affiliations Department of Genome Repair, Atomic Bomb Disease Institute, Nagasaki University Sakamoto, Nagasaki, Japan, Department of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Japan

  ⨯
• Tomoo Ogi,

  Roles Data curation

  Affiliations Department of Genome Repair, Atomic Bomb Disease Institute, Nagasaki University Sakamoto, Nagasaki, Japan, Department of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Japan

  ⨯
• Hiroshi Harada,

  Roles Investigation

  Affiliation Laboratory of Cancer Cell Biology, Radiation Biology Center, Kyoto University, Yoshidakonoe, Sakyo-ku, Kyoto, Japan

  ⨯
• Keli Agama,

  Roles Investigation

  Affiliation Laboratory of Molecular Pharmacology, Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States of America

  ⨯
• Jun Nakamura,

  Roles Investigation

  Affiliation Department of Environmental Sciences and Engineering, University of North Carolina Chapel Hill, North Carolina, United States of America

  ⨯
• Ryuta Asada,

  Roles Investigation

  Affiliation Department of Chemistry, Tokyo Metropolitan University, Minami-Osawa, Hachioji- shi, Tokyo, Japan

  ⨯
• Haruna Fujiike,

  Roles Investigation

  Affiliation Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Yoshidakonoe, Sakyo-ku, Kyoto, Japan

  ⨯
• Tetsushi Sakuma,

  Roles Investigation

  Affiliation Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, Hiroshima, Japan

  ⨯
• Takashi Yamamoto,

  Roles Methodology

  Affiliation Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, Hiroshima, Japan

  ⨯
• Junko Murai,

  Roles Investigation

  Affiliations Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Yoshidakonoe, Sakyo-ku, Kyoto, Japan, Laboratory of Molecular Pharmacology, Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States of America

  ⨯
• Masahiro Hiraoka,

  Roles Investigation

  Affiliation Department of Radiation Oncology, Japanese Red Cross Society Wakayama Medical Center, Komatsubara-Dori, Wakayama, Japan

  ⨯
• Kaoru Koike,

  Roles Investigation

  Affiliation Department of Primary Care and Emergency Medicine, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan

  ⨯
• Yves Pommier,

  Roles Data curation, Writing – review & editing

  Affiliation Laboratory of Molecular Pharmacology, Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States of America

  ⨯
• Shunichi Takeda ,

  Roles Supervision, Writing – review & editing

  * E-mail: khirota@tmu.ac.jp (KH); stakeda@rg.med.kyoto-u.ac.jp (ST)

  Affiliation Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Yoshidakonoe, Sakyo-ku, Kyoto, Japan

  ⨯
•  [ ... ],
• Kouji Hirota

  Roles Data curation, Investigation, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: khirota@tmu.ac.jp (KH); stakeda@rg.med.kyoto-u.ac.jp (ST)

  Affiliations Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Yoshidakonoe, Sakyo-ku, Kyoto, Japan, Department of Chemistry, Tokyo Metropolitan University, Minami-Osawa, Hachioji- shi, Tokyo, Japan

  http://orcid.org/0000-0003-1676-979X

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